DNA甲基转移酶在肝癌发生过程中LEC大鼠中的表达。
Expression of DNA methyltransferase in LEC rats during hepatocarcinogenesis.
作者信息
Miyoshi E, Jain S K, Sugiyama T, Fujii J, Hayashi N, Fusamoto H, Kamada T, Taniguchi N
机构信息
Department of Biochemistry, Osaka University Medical School, Japan.
出版信息
Carcinogenesis. 1993 Apr;14(4):603-5. doi: 10.1093/carcin/14.4.603.
The Long-Evans with a cinnamon-like color (LEC) rat is a mutant of the Long-Evans strain that develops hereditary hepatitis and hepatoma with ageing. Age-related changes in the mRNA expression of DNA methyltransferase (DNA MTase) were examined in livers of LEC rats using Long Evans with an agouti color (LEA) rats as controls. A dramatic increase in the expression of this mRNA was observed in LEC rats at 20 weeks when acute hepatitis appeared. Their high mRNA levels were maintained until 52 weeks of age. The mRNA expression as well as DNA MTase activities were found to be higher in cancer lesions than in adjacent normal tissue. These increases may be related to liver regeneration and to early events in cellular transformation of LEC rats.
具有类似肉桂色的长 Evans 大鼠（LEC 大鼠）是长 Evans 品系的一种突变体，随着年龄增长会发展出遗传性肝炎和肝癌。以具有刺鼠色的长 Evans 大鼠（LEA 大鼠）作为对照，检测了 LEC 大鼠肝脏中 DNA 甲基转移酶（DNA MTase）mRNA 表达的年龄相关性变化。在 20 周龄急性肝炎出现时，LEC 大鼠中该 mRNA 的表达急剧增加。它们的高 mRNA 水平一直维持到 52 周龄。发现癌灶中的 mRNA 表达以及 DNA MTase 活性高于相邻的正常组织。这些增加可能与肝脏再生以及 LEC 大鼠细胞转化的早期事件有关。
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