Shibazaki M, Sugawara T, Nagai K, Shimizu Y, Yamaguchi H, Suzuki K
Microbiology Research Department, Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan.
J Antibiot (Tokyo). 1996 Apr;49(4):340-4. doi: 10.7164/antibiotics.49.340.
YM-47522, a novel antibiotic, was isolated from the culture broth of Bacillus sp. YL-03709B. The antibiotic was purified by centrifugal partition chromatography and ODS column chromatography. It exhibited potent in vitro antifungal activity especially against Rhodotorula acuta and Pichia angusta (MIC: 0.05 and 0.75 microgram/ml, respectively). It also showed moderate or weak antifungal activity against Candida albicans and Cryptococcus neoformans (MIC: 25 and 6.25 micrograms/ml, respectively), whereas it was inactive against filamentous fungi and bacteria.
新型抗生素YM-47522是从芽孢杆菌属YL-03709B的培养液中分离得到的。该抗生素通过离心分配色谱法和ODS柱色谱法进行纯化。它在体外表现出强大的抗真菌活性，尤其是对尖锐红酵母和奥古斯塔毕赤酵母（MIC分别为0.05和0.75微克/毫升）。它对白色念珠菌和新型隐球菌也表现出中度或较弱的抗真菌活性（MIC分别为25和6.25微克/毫升），而对丝状真菌和细菌则无活性。
