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UK-3A，一种来自链霉菌属517-02的新型抗真菌抗生素：发酵、分离、结构解析及生物学特性

UK-3A, a novel antifungal antibiotic from Streptomyces sp. 517-02: fermentation, isolation, structural elucidation and biological properties.

作者信息

Ueki M, Kusumoto A, Hanafi M, Shibata K, Tanaka T, Taniguchi M

机构信息

Faculty of Science, Osaka City University, Japan.

出版信息

J Antibiot (Tokyo). 1997 Jul;50(7):551-5. doi: 10.7164/antibiotics.50.551.

DOI:10.7164/antibiotics.50.551

PMID:9711246

Abstract

A novel antifungal antibiotic, UK-3A, was obtained from the mycelial cake of Streptomyces sp. 517-02. UK-3A was very similar in structure to UK-2A, a structural relative of antimycin A. The antifungal spectrum of UK-3A was relatively broad (MICs for yeasts and filamentous fungi: 1.56-6.25 and 0.39-1.56 micrograms/ml, respectively). The cytotoxic activity of UK-3A was weak (IC50: 18-100 micrograms/ml).

摘要

一种新型抗真菌抗生素UK-3A，是从链霉菌属517-02的菌丝饼中获得的。UK-3A在结构上与抗霉素A的结构相关物UK-2A非常相似。UK-3A的抗真菌谱相对较广（对酵母和丝状真菌的MIC分别为1.56 - 6.25微克/毫升和0.39 - 1.56微克/毫升）。UK-3A的细胞毒性活性较弱（IC50为18 - 100微克/毫升）。