Guinane J E
J Neurol Sci. 1977 May;32(1):1-8. doi: 10.1016/0022-510x(77)90035-1.
Experimental results in rabbits support the hypothesis that occlusion of the cerebral subarachnoid space, resulting in an increased strain-stress ratio in the ventricular wall, is the mechanical basis of chronic progressive hydrocephalus within a rigid skull. When the cerebral subarachnoid space was drained through an artificial low-resistance fluid pathway, the wall of the olfactory ventricle showed edema that was indistinguishable from the edema of kaolin hydrocephalus. Increased CSF pressure did not produce edema of this grade when the cerebral subarachnoid space was patent. When the subarachnoid space surrounding the right olfactory bulb was occluded with silicone rubber, the right but not the left olfactory ventricle enlarged; resistance to cerebrospinal fluid absorption remained normal.
脑蛛网膜下腔阻塞导致心室壁应变-应力比增加，是刚性颅骨内慢性进行性脑积水的力学基础。当通过人工低阻力液体通路引流脑蛛网膜下腔时，嗅脑室壁出现的水肿与高岭土性脑积水的水肿无法区分。当脑蛛网膜下腔通畅时，脑脊液压力升高不会产生这种程度的水肿。当用硅橡胶阻塞右嗅球周围的蛛网膜下腔时，右侧而非左侧的嗅脑室扩大；脑脊液吸收阻力仍保持正常。
