犬长时间禁食对葡萄糖代谢及血液代谢物的影响。

Influence of prolonged fasting in the dog on glucose turnover and blood metabolites.

作者信息

Brady L J, Armstrong M K, Muiruri K L, Romsos D R, Bergen W G, Leveille G A

出版信息

J Nutr. 1977 Jun;107(6):1053-60. doi: 10.1093/jn/107.6.1053.

DOI:10.1093/jn/107.6.1053

Abstract

Glucose turnover and blood metabolites were measured in eight adult female beagles in the fed state, at 1 day of fasting, and at 7, 14, and 21 days of fasting. Glucose utilization decreased significantly from 1 to 7 days of fasting, but remained constant from 7 to 21 days, while blood ketones and plasma free fatty acids rose significantly during the same period. Plasma alanine, serine, and glycine fell with fasting, with the greatest decrease in alanine levels occurring between 7 to 14 days. Plasma branched chain amino acids rose significantly with fasting. It was concluded that the shifts in plasma metabolites and decreased glucose utilization could be indicative of decreased energy demands of the fasting dogs and/or a shift in substrate utilization with progressive fasting.

摘要

在八只成年雌性比格犬处于进食状态、禁食1天、禁食7天、14天和21天时，测量了葡萄糖周转率和血液代谢物。从禁食第1天到第7天，葡萄糖利用率显著下降，但从第7天到第21天保持恒定，而在此期间血液酮体和血浆游离脂肪酸显著上升。血浆丙氨酸、丝氨酸和甘氨酸随着禁食而下降，丙氨酸水平在7至14天之间下降最为明显。血浆支链氨基酸随着禁食显著上升。得出的结论是，血浆代谢物的变化和葡萄糖利用率的降低可能表明禁食犬的能量需求降低和/或随着禁食的进展底物利用发生了变化。