神经营养因子及其受体在鸡神经元发育中的作用
Neurotrophins and their receptors in chicken neuronal development.
作者信息
Hallbook F, Bäckström A, Kullander K, Kylberg A, Williams R, Ebendal T
机构信息
Department of Developmental Neuroscience, Uppsala University, Biomedial Center, Sweden.
出版信息
Int J Dev Biol. 1995 Oct;39(5):855-68.
A review on current studies of chicken neurotrophins and their receptors is given. Chicken NGF, BDNF and NT-3 have been cloned and sequences have been used to synthesize oligonucleotides for specific localization of expression during development. Also, chicken TrkA, TrkB and TrkC have been cloned, sequenced and studied by in situ hybridization. Recombinant NT-3 was applied to chicken ganglia at different developmental stages to examine acquirement of responsiveness to NT-3 compared to NGF. Phylogenetic analyses of the chicken neurotrophins and Trk receptors were carried out based on parsimony. Finally, some data on apoptosis in chicken embryo sympathetic ganglia are presented.
本文对鸡神经营养因子及其受体的当前研究进行了综述。鸡神经生长因子（NGF）、脑源性神经营养因子（BDNF）和神经营养因子-3（NT-3）已被克隆，其序列已被用于合成寡核苷酸，以在发育过程中进行特异性表达定位。此外，鸡酪氨酸激酶A（TrkA）、酪氨酸激酶B（TrkB）和酪氨酸激酶C（TrkC）已被克隆、测序并通过原位杂交进行研究。将重组NT-3应用于不同发育阶段的鸡神经节，以检查与NGF相比对NT-3反应性的获得情况。基于简约法对鸡神经营养因子和Trk受体进行了系统发育分析。最后，给出了一些关于鸡胚交感神经节细胞凋亡的数据。
Zotero 插件