Hutzelmann A, Palmié S, Zimmer C, Benz T, Leweke F, Freund M
Klinik für Radiologische Diagnostik, Christian-Albrechts-Universität zu Kiel.
Rofo. 1996 Apr;164(4):314-7. doi: 10.1055/s-2007-1015661.
To evaluate the occurrence of the meningeal sign in meningiomas and metastases.
We studied 20 patients with meningiomas and 17 patients with cerebral metastases adjacent to the dura. MRI studies (Siemens, Magnetom 1,5) included axial T1-weighted and T2-weighted unenhanced as well as gadolinium-DTPA enhanced T1-weighted (axial, coronal, sagittal) SE imaging. In all patients the tumours were resected with the attached dura mater. Histopathological examinations were done, which corresponded to the area of marked enhancement by gadolinium-DTPA. There was no correlation between the occurrence of the meningeal sign and the histopathological examinations.
In 20 patients with meningiomas adjacent to the dura we found the meningeal sign in 11 cases. Histologically we observed an increase of collagen fibres and fibrocytes. In 5 of 17 cases with superficial cerebral metastases the meningeal sign was seen, histologically as dura infiltrations and microbleedings.
The meningeal sign is not specific for meningiomas and can be observed in a wide variety of pathological entities.
评估脑膜瘤和转移瘤中脑膜征的出现情况。
我们研究了20例脑膜瘤患者和17例紧邻硬脑膜的脑转移瘤患者。MRI检查（西门子，Magnetom 1.5）包括轴位T1加权和T2加权平扫以及钆喷酸葡胺增强T1加权（轴位、冠状位、矢状位）SE成像。所有患者均切除肿瘤及其附着的硬脑膜。进行了组织病理学检查，其对应于钆喷酸葡胺明显强化的区域。脑膜征的出现与组织病理学检查之间无相关性。
在20例紧邻硬脑膜的脑膜瘤患者中，我们在11例中发现了脑膜征。组织学上我们观察到胶原纤维和纤维细胞增多。在17例浅表性脑转移瘤患者中的5例中可见脑膜征，组织学表现为硬脑膜浸润和微出血。
脑膜征并非脑膜瘤所特有，可在多种病理实体中观察到。
