使用Omnix血细胞分离机获得的血小板浓缩物的在线过滤。

In-line filtration of platelet concentrates obtained with the Omnix blood cell separator.

作者信息

Moog R, Müller N, Nieper A

机构信息

Institute for Transfusion Medicine, University Clinics, Essen, Germany.

出版信息

Transfus Med. 1995 Dec;5(4):293-6. doi: 10.1111/j.1365-3148.1995.tb00218.x.

DOI:10.1111/j.1365-3148.1995.tb00218.x

PMID:8646295

Abstract

The quality of platelet concentrates (PC) obtained with the blood cell separator Omnix was investigated before and after in-line filtration. PC were filtered 2h (protocol A) and 4 h (protocol B) after the termination of apheresis. Platelet (PLT) yield after filtration was similar in both protocols (median 3.7 vs. 3.4 x 10(11)). Median white blood cell (WBC) contamination after leucocyte depletion was 0.07 x 10(6) (range 0.02-3.27 x 10(6)) in protocol A and 0.06 x 10(6) (range 0.02-2.1 x 10(6)) in protocol B. Glucose, lactate, lactate dehydrogenase, morphology score and pH value were not statistically different before and after filtration in both protocols. We conclude that in-line filtration results in sufficient leucocyte depletion of the PC. The prefiltration storage time did not influence the studied parameters of product quality.

摘要

对使用血细胞分离机Omnix获取的血小板浓缩物（PC）在进行在线过滤前后的质量进行了研究。在单采结束后2小时（方案A）和4小时（方案B）对PC进行过滤。两种方案过滤后的血小板（PLT）产量相似（中位数分别为3.7×10¹¹和3.4×10¹¹）。在方案A中，白细胞去除后白细胞（WBC）污染的中位数为0.07×10⁶（范围为0.02 - 3.27×10⁶），在方案B中为0.06×10⁶（范围为0.02 - 2.1×10⁶）。在两种方案中，过滤前后的葡萄糖、乳酸、乳酸脱氢酶、形态学评分和pH值均无统计学差异。我们得出结论，在线过滤可使PC充分去除白细胞。过滤前的储存时间不影响所研究的产品质量参数。