• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Extragenic suppressors of nudC3, a mutation that blocks nuclear migration in Aspergillus nidulans.nudC3的基因外抑制因子，nudC3是一种阻止构巢曲霉核迁移的突变。
Genetics. 1995 Oct;141(2):453-64. doi: 10.1093/genetics/141.2.453.
2
Mutations in the heavy chain of cytoplasmic dynein suppress the nudF nuclear migration mutation of Aspergillus nidulans.细胞质动力蛋白重链中的突变抑制了构巢曲霉的nudF核迁移突变。
Mol Gen Genet. 1997 Jun;255(2):194-200. doi: 10.1007/s004380050489.
3
NudF, a nuclear migration gene in Aspergillus nidulans, is similar to the human LIS-1 gene required for neuronal migration.NudF是构巢曲霉中的一个核迁移基因，与神经元迁移所需的人类LIS-1基因相似。
Mol Biol Cell. 1995 Mar;6(3):297-310. doi: 10.1091/mbc.6.3.297.
4
An alpha tubulin mutation suppresses nuclear migration mutations in Aspergillus nidulans.α-微管蛋白突变抑制构巢曲霉中的核迁移突变。
Genetics. 1995 Dec;141(4):1287-98. doi: 10.1093/genetics/141.4.1287.
5
Genetic and molecular analysis of a tRNA(Leu) missense suppressor of nudC3, a mutation that blocks nuclear migration in Aspergillus nidulans.构巢曲霉中nudC3突变（该突变阻断核迁移）的tRNA（亮氨酸）错义抑制子的遗传与分子分析。
Genetics. 1997 Mar;145(3):707-14. doi: 10.1093/genetics/145.3.707.
6
The molecular cloning and identification of a gene product specifically required for nuclear movement in Aspergillus nidulans.构巢曲霉核运动特别所需的一种基因产物的分子克隆与鉴定。
J Cell Biol. 1990 Aug;111(2):543-51. doi: 10.1083/jcb.111.2.543.
7
Extragenic suppressors of a dynein mutation that blocks nuclear migration in Aspergillus nidulans.一种阻止构巢曲霉核迁移的动力蛋白突变的基因外抑制子。
Genetics. 1995 Mar;139(3):1223-32. doi: 10.1093/genetics/139.3.1223.
8
Cytoplasmic dynein is involved in nuclear migration in Aspergillus nidulans.细胞质动力蛋白参与构巢曲霉中的核迁移。
Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2100-4. doi: 10.1073/pnas.91.6.2100.
9
Deletion of nudC, a nuclear migration gene of Aspergillus nidulans, causes morphological and cell wall abnormalities and is lethal.构巢曲霉的核迁移基因nudC缺失会导致形态和细胞壁异常，且是致死性的。
Mol Biol Cell. 1997 Sep;8(9):1735-49. doi: 10.1091/mbc.8.9.1735.
10
Isolation of a new set of Aspergillus nidulans mutants defective in nuclear migration.分离出一组新的在核迁移方面存在缺陷的构巢曲霉突变体。
Curr Genet. 1999 Jul;35(6):626-30. doi: 10.1007/s002940050461.

引用本文的文献

1
Small Sized Yet Powerful: Nuclear Distribution C Proteins in Plants.小巧却强大：植物中的核分布C蛋白
Plants (Basel). 2023 Dec 31;13(1):119. doi: 10.3390/plants13010119.
2
Nuclear movement in fungi.真菌中的核运动。
Semin Cell Dev Biol. 2018 Oct;82:3-16. doi: 10.1016/j.semcdb.2017.10.024. Epub 2017 Dec 11.
3
ASYMMETRIC-LEAVES2 and an ortholog of eukaryotic NudC domain proteins repress expression of AUXIN-RESPONSE-FACTOR and class 1 KNOX homeobox genes for development of flat symmetric leaves in Arabidopsis.不对称叶 2 蛋白和真核生物 NudC 结构域蛋白的同源物抑制拟南芥 AUXIN-RESPONSE-FACTOR 和类 1 KNOX 同源盒基因的表达，从而使叶片发育成扁平对称。
Biol Open. 2012 Mar 15;1(3):197-207. doi: 10.1242/bio.2012406. Epub 2012 Jan 6.
4
NudC is required for interkinetic nuclear migration and neuronal migration during neocortical development.NudC 对于新皮层发育过程中的核迁移和神经元迁移是必需的。
Dev Biol. 2011 Sep 15;357(2):326-35. doi: 10.1016/j.ydbio.2011.07.001. Epub 2011 Jul 13.
5
The L279P mutation of nuclear distribution gene C (NudC) influences its chaperone activity and lissencephaly protein 1 (LIS1) stability.核分布基因 C（NudC）的 L279P 突变影响其伴侣活性和无脑回蛋白 1（LIS1）的稳定性。
J Biol Chem. 2010 Sep 24;285(39):29903-10. doi: 10.1074/jbc.M110.105494. Epub 2010 Jul 30.
6
NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90.NudC 样蛋白 2 通过与热休克蛋白 90 稳定 LIS1 来调节 LIS1/动力蛋白途径。
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3499-504. doi: 10.1073/pnas.0914307107. Epub 2010 Feb 3.
7
The mammalian NudC-like genes: a family with functions other than regulating nuclear distribution.哺乳动物类NudC基因：一个具有调控核分布以外功能的基因家族。
Cell Mol Life Sci. 2009 Jul;66(14):2383-90. doi: 10.1007/s00018-009-0025-3. Epub 2009 Apr 18.
8
Deletion of nudC, a nuclear migration gene of Aspergillus nidulans, causes morphological and cell wall abnormalities and is lethal.构巢曲霉的核迁移基因nudC缺失会导致形态和细胞壁异常，且是致死性的。
Mol Biol Cell. 1997 Sep;8(9):1735-49. doi: 10.1091/mbc.8.9.1735.
9
Genetic and molecular analysis of a tRNA(Leu) missense suppressor of nudC3, a mutation that blocks nuclear migration in Aspergillus nidulans.构巢曲霉中nudC3突变（该突变阻断核迁移）的tRNA（亮氨酸）错义抑制子的遗传与分子分析。
Genetics. 1997 Mar;145(3):707-14. doi: 10.1093/genetics/145.3.707.
10
Isolation of two apsA suppressor strains in Aspergillus nidulans.在构巢曲霉中分离出两株apsA抑制菌株。
Genetics. 1996 Oct;144(2):533-40. doi: 10.1093/genetics/144.2.533.

本文引用的文献

1
BIMA, a TPR-containing protein required for mitosis, localizes to the spindle pole body in Aspergillus nidulans.BIMA是一种有丝分裂所需的含TPR结构域的蛋白质，定位于构巢曲霉的纺锤极体。
J Cell Biol. 1993 Feb;120(4):959-68. doi: 10.1083/jcb.120.4.959.
2
New roles for G-protein beta gamma-dimers in transmembrane signalling.G蛋白βγ二聚体在跨膜信号传导中的新作用。
Nature. 1993 Sep 30;365(6445):403-6. doi: 10.1038/365403a0.
3
Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats.一个含有G蛋白β亚基样重复序列的米勒-迪克尔平滑脑基因的分离。
Nature. 1993 Aug 19;364(6439):717-21. doi: 10.1038/364717a0.
4
Cytoplasmic dynein is required for normal nuclear segregation in yeast.细胞质动力蛋白是酵母正常核分离所必需的。
Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11172-6. doi: 10.1073/pnas.90.23.11172.
5
Disruption of mitotic spindle orientation in a yeast dynein mutant.酵母动力蛋白突变体中纺锤体取向的破坏。
Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10096-100. doi: 10.1073/pnas.90.21.10096.
6
Cytoplasmic dynein is involved in nuclear migration in Aspergillus nidulans.细胞质动力蛋白参与构巢曲霉中的核迁移。
Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2100-4. doi: 10.1073/pnas.91.6.2100.
7
BFR1, a multicopy suppressor of brefeldin A-induced lethality, is implicated in secretion and nuclear segregation in Saccharomyces cerevisiae.BFR1是布雷菲德菌素A诱导致死性的多拷贝抑制因子，参与酿酒酵母的分泌和核分离过程。
Genetics. 1994 Jun;137(2):423-37. doi: 10.1093/genetics/137.2.423.
8
A yeast actin-related protein homologous to that in vertebrate dynactin complex is important for spindle orientation and nuclear migration.一种与脊椎动物动力蛋白复合体中的蛋白同源的酵母肌动蛋白相关蛋白，对纺锤体定向和核迁移很重要。
Cell. 1994 Aug 26;78(4):669-79. doi: 10.1016/0092-8674(94)90531-2.
9
Cytoplasmic dynein and actin-related protein Arp1 are required for normal nuclear distribution in filamentous fungi.细胞质动力蛋白和肌动蛋白相关蛋白Arp1是丝状真菌正常核分布所必需的。
J Cell Biol. 1994 Oct;127(1):139-149. doi: 10.1083/jcb.127.1.139.
10
ACT3: a putative centractin homologue in S. cerevisiae is required for proper orientation of the mitotic spindle.ACT3：酿酒酵母中一种假定的中心肌动蛋白同源物是有丝分裂纺锤体正确定向所必需的。
J Cell Biol. 1994 Oct;127(1):129-38. doi: 10.1083/jcb.127.1.129.

nudC3的基因外抑制因子，nudC3是一种阻止构巢曲霉核迁移的突变。

Extragenic suppressors of nudC3, a mutation that blocks nuclear migration in Aspergillus nidulans.

作者信息

Chiu Y H, Morris N R

机构信息

Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School, Piscataway 08854, USA.

出版信息

Genetics. 1995 Oct;141(2):453-64. doi: 10.1093/genetics/141.2.453.

DOI:10.1093/genetics/141.2.453
PMID:8647384
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1206747/
Abstract

Nuclear migration plays an important role in the growth and development of many organisms including the filamentous fungus Aspergillus nidulans. We have cloned three genes from A. nidulans, nudA, nudC, and nudF, in which mutations affect nuclear migration. The nudA gene encodes the heavy chain of cytoplasmic dynein. The nudC gene encodes a 22-kD protein. The nudF gene was identified as an extra copy suppressor of the temperature sensitive (ts-) nudC3 mutation. The nudC3 mutation substantially decreases the intracellular concentration of the nudF protein at restrictive temperature. This is restored toward the normal level by an extra copy of nudF. To identify other genes whose products interact directly or indirectly with the NUDC protein, we have isolated a set of extragenic suppressors showed them to represent nine different genes, designated sncA-sncI (for suppressor of nudC). sncA-sncH were either dominant or semidominant in diploids homozygous for nudC3 and heterozygous for the snc mutations. All of the suppressors reversed the ts- phenotype of nudC3 by restoring the intracellular concentration of the NUDF protein.

摘要

核迁移在包括丝状真菌构巢曲霉在内的许多生物体的生长和发育过程中发挥着重要作用。我们从构巢曲霉中克隆了三个基因，nudA、nudC和nudF，其中的突变会影响核迁移。nudA基因编码细胞质动力蛋白的重链。nudC基因编码一种22-kD的蛋白质。nudF基因被鉴定为温度敏感型（ts-）nudC3突变的额外拷贝抑制子。在限制温度下，nudC3突变会大幅降低nudF蛋白的细胞内浓度。通过nudF的额外拷贝，这一浓度会恢复到正常水平。为了鉴定其产物与NUDC蛋白直接或间接相互作用的其他基因，我们分离出了一组基因外抑制子，发现它们代表九个不同的基因，命名为sncA-sncI（nudC的抑制子）。sncA-sncH在nudC3纯合且snc突变杂合的二倍体中要么是显性的，要么是半显性的。所有这些抑制子都通过恢复NUDF蛋白的细胞内浓度，逆转了nudC3的ts-表型。