Experimental study of combined hyperthermic and photodynamic therapy on carcinoma in the mouse.
作者信息
Uehara M, Inokuchi T, Sano K
机构信息
Second Department of Oral and Maxillofacial Surgery, Nagasaki University School of Dentistry, Japan.
出版信息
J Oral Maxillofac Surg. 1996 Jun;54(6):729-36; discussion 736-7. doi: 10.1016/s0278-2391(96)90692-8.
PURPOSE
This study investigates the cytotoxic effect of photodynamic therapy using high-power laser irradiation on cancer cells.
MATERIALS AND METHODS
High- or low-power irradiation from a pulsed Nd:YAG dye laser with or without a photosensitizer was administered to an NR-S1 carcinoma in the mouse dorsum.
RESULTS
Photodynamic therapy with high-power laser irradiation yielded better results than conventional photodynamic therapy or hyperthermia with high-power laser irradiation.
CONCLUSION
Photodynamic therapy with high-power laser irradiation is more effective because it generates both a hyperthermic and a photodynamic effect.
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