Arai T, Hashimoto Y, Shima T, Matsukawa S, Iwatsuki K I
Jpn J Antibiot. 1977 Apr;30(4):281-4.
Neuromuscular blocking properties of tobramycin (Tobracin 60mg), dibekacin (Panmycin 100 mg) and ribostamycin (Vistamycin 1g) were studied in man during anesthesia and surgery by observing the effects of these antibiotics on muscle twitch tension. These antibiotics alone did not show any neuromuscular blocking action in the therapeutic doses. The neuromuscular blocking action of d-tubocurarine chloride was potentiated by the intravenous administration of 1g of ribostamycin. Tobramycin 60mg did not show remarkable effect, but dibekacin 100mg produced a slight potentiating effect on the action of d-tubocurarine. The enhancement of the action of d-tubocurarine was anatagonized by edrophonium and calcium. The action of succinylcholine chloride was not affected by tobramycin or ribostamycin, but it was potentiated transitorily by dibekacin. It is advisable to pay attention to possible respiratory depression when ribostamycin and dibekacin and used in combination with non-depolarizing muscle relaxants and/or anesthetics.
在麻醉和手术期间，通过观察妥布霉素（托百士60毫克）、地贝卡星（潘美星100毫克）和核糖霉素（威他霉素1克）对肌肉抽搐张力的影响，研究了它们在人体中的神经肌肉阻滞特性。这些抗生素在治疗剂量下单独使用时未显示出任何神经肌肉阻滞作用。静脉注射1克核糖霉素可增强氯化筒箭毒碱的神经肌肉阻滞作用。60毫克妥布霉素未显示出显著效果，但100毫克地贝卡星对氯化筒箭毒碱的作用产生了轻微的增强作用。依酚氯铵和钙可拮抗氯化筒箭毒碱作用的增强。氯化琥珀胆碱的作用不受妥布霉素或核糖霉素的影响，但地贝卡星可使其短暂增强。当核糖霉素和地贝卡星与非去极化肌肉松弛剂和/或麻醉剂联合使用时，应注意可能出现的呼吸抑制。
