Hashimoto Y, Shima T, Matsukawa S, Iwatsuki K
Tohoku J Exp Med. 1975 Dec;117(4):399-400. doi: 10.1620/tjem.117.399.
Neuromuscular blocking properties of ribostamycin (1 gm), dibecacin (100 mg) and tobramycin (60 mg) were studied in a man during anesthesia and surgery by observing the effects of these antibiotics on muscle twitch tension. These drugs alone did not show any neuromuscular blocking action in those therapeutic doses. However, during the recovery phase of d-tubocurarine block the intravenous administration of 1 gm of ribostamycin caused a fairly rapid decrease in twitch tension. Tobramycin 60 mg did not show any remarkable effect, but dibecacin 100 mg produced a slight potentiating effect on the action of d-tubocurarine. The enhancement of the action of d-tubocurarine was antagonized promptly by edrophonium and more slowly by calcium.
在麻醉和手术期间，通过观察这些抗生素对肌肉抽搐张力的影响，研究了核糖霉素（1克）、双去甲氧基庆大霉素（100毫克）和妥布霉素（60毫克）对一名男性的神经肌肉阻滞特性。这些药物在治疗剂量下单独使用时未显示出任何神经肌肉阻滞作用。然而，在右旋筒箭毒碱阻滞的恢复期，静脉注射1克核糖霉素导致抽搐张力相当迅速地下降。60毫克妥布霉素未显示出任何显著效果，但100毫克双去甲氧基庆大霉素对右旋筒箭毒碱的作用产生了轻微的增强作用。依酚氯铵能迅速拮抗右旋筒箭毒碱作用的增强，而钙拮抗作用则较慢。
