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1
Regulated, stable expression and nuclear presence of reovirus double-stranded RNA-binding protein sigma3 in HeLa cells.呼肠孤病毒双链RNA结合蛋白sigma3在HeLa细胞中的表达受调控、稳定且定位于细胞核。
J Virol. 1996 Jun;70(6):3497-501. doi: 10.1128/JVI.70.6.3497-3501.1996.
2
Double-stranded RNA-dependent protein kinase (PKR) is regulated by reovirus structural proteins.双链RNA依赖性蛋白激酶（PKR）受呼肠孤病毒结构蛋白调控。
Virology. 1997 Aug 4;234(2):364-71. doi: 10.1006/viro.1997.8664.
3
Reovirus σ3 Protein Limits Interferon Expression and Cell Death Induction.呼肠孤病毒 σ3 蛋白限制干扰素表达和细胞死亡诱导。
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4
Structure of the reovirus outer capsid and dsRNA-binding protein sigma3 at 1.8 A resolution.呼肠孤病毒外衣壳及双链RNA结合蛋白σ3在1.8埃分辨率下的结构
EMBO J. 2001 Mar 1;20(5):979-89. doi: 10.1093/emboj/20.5.979.
5
Reovirus variants selected for resistance to ammonium chloride have mutations in viral outer-capsid protein sigma3.选择出的对氯化铵具有抗性的呼肠孤病毒变体在病毒外衣壳蛋白sigma3中存在突变。
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Components of the Reovirus Capsid Differentially Contribute to Stability.呼肠孤病毒衣壳的组成部分对稳定性有不同的贡献。
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Reovirus virion-like particles obtained by recoating infectious subvirion particles with baculovirus-expressed sigma3 protein: an approach for analyzing sigma3 functions during virus entry.通过用杆状病毒表达的sigma3蛋白重新包被感染性亚病毒颗粒获得的呼肠孤病毒病毒样颗粒：一种分析病毒进入过程中sigma3功能的方法。
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Protease cleavage of reovirus capsid protein mu1/mu1C is blocked by alkyl sulfate detergents, yielding a new type of infectious subvirion particle.呼肠孤病毒衣壳蛋白mu1/mu1C的蛋白酶切割被烷基硫酸盐去污剂阻断，产生一种新型的感染性子病毒颗粒。
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Preferential translation of reovirus mRNA by a sigma3-dependent mechanism.呼肠孤病毒mRNA通过σ3依赖机制进行优先翻译。
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10
Structure of the reovirus membrane-penetration protein, Mu1, in a complex with is protector protein, Sigma3.呼肠孤病毒膜穿透蛋白Mu1与保护蛋白Sigma3形成的复合物的结构。
Cell. 2002 Jan 25;108(2):283-95. doi: 10.1016/s0092-8674(02)00612-8.

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Mammalian orthoreovirus capsid protein σ3 antagonizes RLR-mediated antiviral responses by degrading MAVS.哺乳动物正呼肠孤病毒衣壳蛋白 σ3 通过降解 MAVS 拮抗 RLR 介导的抗病毒反应。
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The multi-functional reovirus σ3 protein is a virulence factor that suppresses stress granule formation and is associated with myocardial injury.多功能呼肠孤病毒 σ3 蛋白是一种毒力因子，它抑制应激颗粒的形成，并与心肌损伤有关。
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Synthesis and Translation of Viral mRNA in Reovirus-Infected Cells: Progress and Remaining Questions.呼肠孤病毒感染细胞中病毒 mRNA 的合成与翻译：进展与遗留问题。
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7
Detection of a fourth orbivirus non-structural protein.检测到第四种环状病毒非结构蛋白。
PLoS One. 2011;6(10):e25697. doi: 10.1371/journal.pone.0025697. Epub 2011 Oct 12.
8
Reovirus outer capsid protein micro1 induces apoptosis and associates with lipid droplets, endoplasmic reticulum, and mitochondria.呼肠孤病毒外衣壳蛋白μ1诱导细胞凋亡，并与脂滴、内质网和线粒体相关联。
J Virol. 2006 Sep;80(17):8422-38. doi: 10.1128/JVI.02601-05.
9
Reovirus sigma NS and mu NS proteins form cytoplasmic inclusion structures in the absence of viral infection.呼肠孤病毒σNS蛋白和μNS蛋白在无病毒感染的情况下形成细胞质包涵体结构。
J Virol. 2003 May;77(10):5948-63. doi: 10.1128/jvi.77.10.5948-5963.2003.
10
Structure of the reovirus outer capsid and dsRNA-binding protein sigma3 at 1.8 A resolution.呼肠孤病毒外衣壳及双链RNA结合蛋白σ3在1.8埃分辨率下的结构
EMBO J. 2001 Mar 1;20(5):979-89. doi: 10.1093/emboj/20.5.979.

本文引用的文献

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Nuclear localization of a double-stranded RNA-binding protein encoded by the vaccinia virus E3L gene.痘苗病毒E3L基因编码的双链RNA结合蛋白的核定位
Virology. 1993 Aug;195(2):732-44. doi: 10.1006/viro.1993.1424.
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Mutational analysis of the cation-independent mannose 6-phosphate/insulin-like growth factor II receptor. A consensus casein kinase II site followed by 2 leucines near the carboxyl terminus is important for intracellular targeting of lysosomal enzymes.非依赖阳离子的甘露糖6-磷酸/胰岛素样生长因子II受体的突变分析。靠近羧基末端的一个共有酪蛋白激酶II位点后接两个亮氨酸，对溶酶体酶的细胞内靶向定位很重要。
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Mutations in a CCHC zinc-binding motif of the reovirus sigma 3 protein decrease its intracellular stability.呼肠孤病毒σ3蛋白的CCHC锌结合基序中的突变会降低其细胞内稳定性。
J Virol. 1994 Aug;68(8):5287-90. doi: 10.1128/JVI.68.8.5287-5290.1994.
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Site-directed mutagenic analysis of reovirus sigma 3 protein binding to dsRNA.呼肠孤病毒σ3蛋白与双链RNA结合的定点诱变分析
Virology. 1994 Oct;204(1):190-9. doi: 10.1006/viro.1994.1523.
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Rescue of vaccinia virus lacking the E3L gene by mutants of E3L.通过E3L突变体拯救缺失E3L基因的痘苗病毒。
J Virol. 1995 Oct;69(10):6605-8. doi: 10.1128/JVI.69.10.6605-6608.1995.
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Nuclear export signals and the fast track to the cytoplasm.核输出信号与通向细胞质的快速通道。
Cell. 1995 Aug 11;82(3):341-4. doi: 10.1016/0092-8674(95)90420-4.
7
Structure of the dsRNA binding domain of E. coli RNase III.大肠杆菌核糖核酸酶III双链RNA结合结构域的结构
EMBO J. 1995 Jul 17;14(14):3572-84. doi: 10.1002/j.1460-2075.1995.tb07363.x.
8
NMR solution structure of a dsRNA binding domain from Drosophila staufen protein reveals homology to the N-terminal domain of ribosomal protein S5.果蝇Staufen蛋白双链RNA结合结构域的核磁共振溶液结构显示与核糖体蛋白S5的N端结构域具有同源性。
EMBO J. 1995 Jul 17;14(14):3563-71. doi: 10.1002/j.1460-2075.1995.tb07362.x.
9
TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR.TAR RNA结合蛋白是干扰素诱导蛋白激酶PKR的一种抑制剂。
Proc Natl Acad Sci U S A. 1994 May 24;91(11):4713-7. doi: 10.1073/pnas.91.11.4713.
10
The interaction of mammalian reoviruses with the cytoskeleton of monkey kidney CV-1 cells.哺乳动物呼肠孤病毒与猴肾CV-1细胞细胞骨架的相互作用。
Virology. 1982 Jul 30;120(2):399-411. doi: 10.1016/0042-6822(82)90040-x.

呼肠孤病毒双链RNA结合蛋白sigma3在HeLa细胞中的表达受调控、稳定且定位于细胞核。

Regulated, stable expression and nuclear presence of reovirus double-stranded RNA-binding protein sigma3 in HeLa cells.

作者信息

Yue Z, Shatkin A J

机构信息

Graduate Program in Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, USA.

出版信息

J Virol. 1996 Jun;70(6):3497-501. doi: 10.1128/JVI.70.6.3497-3501.1996.

DOI:10.1128/JVI.70.6.3497-3501.1996
PMID:8648682
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC190223/
Abstract

Reovirus genome segment S4 codes for polypeptide sigma3, a major outer capsid component of virions and a double-stranded RNA (dsRNA)-binding protein implicated in viral cytopathogenesis. We have constructed a stable HeLa cell line (S4tTA) that produces functional sigma3 under tetracycline transactivator control. In the absence of tetracycline, S4tTA cells synthesized stable dsRNA-binding sigma3 that accumulated in the nucleus as well as in the cytoplasm. However, in induced S4tTA cells also expressing reovirus outer shell polypeptide mu1/mu1C, migration of sigma3 into the nucleus was blocked, probably as a result of formation of a complex with mu1/mu1C which was exclusively in the cytoplasm. Mutant analyses indicated a correlation between dsRNA-binding activity and nuclear entry of sigma3, suggesting an additional role(s) for this capsid protein in virus-cell interactions.

摘要

呼肠孤病毒基因组片段S4编码σ3多肽，它是病毒粒子的主要外衣壳成分，也是一种双链RNA（dsRNA）结合蛋白，与病毒细胞病变机制有关。我们构建了一个稳定的HeLa细胞系（S4tTA），该细胞系在四环素反式激活因子的控制下产生功能性σ3。在没有四环素的情况下，S4tTA细胞合成稳定的dsRNA结合性σ3，其在细胞核和细胞质中积累。然而，在诱导的同时也表达呼肠孤病毒外壳多肽μ1/μ1C的S4tTA细胞中，σ3向细胞核的迁移被阻断了，这可能是由于与仅存在于细胞质中的μ1/μ1C形成复合物的结果。突变分析表明dsRNA结合活性与σ3的核进入之间存在相关性，这表明这种衣壳蛋白在病毒-细胞相互作用中还有其他作用。