• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Rescue of vaccinia virus lacking the E3L gene by mutants of E3L.通过E3L突变体拯救缺失E3L基因的痘苗病毒。
J Virol. 1995 Oct;69(10):6605-8. doi: 10.1128/JVI.69.10.6605-6608.1995.
2
Complementation of vaccinia virus deleted of the E3L gene by mutants of E3L.通过E3L突变体对缺失E3L基因的痘苗病毒进行互补。
Virology. 1997 Dec 22;239(2):269-76. doi: 10.1006/viro.1997.8881.
3
Reversal of the interferon-sensitive phenotype of a vaccinia virus lacking E3L by expression of the reovirus S4 gene.通过呼肠孤病毒S4基因的表达逆转缺乏E3L的痘苗病毒的干扰素敏感表型。
J Virol. 1995 Jan;69(1):499-505. doi: 10.1128/JVI.69.1.499-505.1995.
4
The role of the PKR-inhibitory genes, E3L and K3L, in determining vaccinia virus host range.蛋白激酶R抑制基因E3L和K3L在决定痘苗病毒宿主范围中的作用。
Virology. 2002 Jul 20;299(1):133-41. doi: 10.1006/viro.2002.1479.
5
Complementation of deletion of the vaccinia virus E3L gene by the Escherichia coli RNase III gene.大肠杆菌RNase III基因对痘苗病毒E3L基因缺失的互补作用。
Virology. 1997 Jan 6;227(1):77-87. doi: 10.1006/viro.1996.8319.
6
Host-range restriction of vaccinia virus E3L-specific deletion mutants.痘苗病毒E3L特异性缺失突变体的宿主范围限制
Virus Genes. 1996;12(1):89-94. doi: 10.1007/BF00370005.
7
siRNA targeting vaccinia virus double-stranded RNA binding protein [E3L] exerts potent antiviral effects.靶向痘苗病毒双链RNA结合蛋白[E3L]的小干扰RNA发挥强大的抗病毒作用。
Virology. 2006 May 10;348(2):489-97. doi: 10.1016/j.virol.2006.01.013. Epub 2006 Feb 9.
8
Replication of modified vaccinia virus Ankara in primary chicken embryo fibroblasts requires expression of the interferon resistance gene E3L.改良安卡拉痘苗病毒在原代鸡胚成纤维细胞中的复制需要干扰素抗性基因E3L的表达。
J Virol. 2003 Aug;77(15):8394-407. doi: 10.1128/jvi.77.15.8394-8407.2003.
9
Identification of a conserved motif that is necessary for binding of the vaccinia virus E3L gene products to double-stranded RNA.鉴定一种保守基序，该基序是痘苗病毒E3L基因产物与双链RNA结合所必需的。
Virology. 1993 Jun;194(2):537-47. doi: 10.1006/viro.1993.1292.
10
Antagonizing activity of vaccinia virus E3L against human interferons in Huh7 cells.痘苗病毒E3L在Huh7细胞中对人干扰素的拮抗活性。
Virology. 2008 Jul 20;377(1):124-32. doi: 10.1016/j.virol.2008.04.014. Epub 2008 May 27.

引用本文的文献

1
Host species-specific activity of the poxvirus PKR inhibitors E3 and K3 mediate host range function.痘病毒 PKR 抑制剂 E3 和 K3 的宿主物种特异性活性介导宿主范围功能。
J Virol. 2024 Nov 19;98(11):e0133124. doi: 10.1128/jvi.01331-24. Epub 2024 Oct 31.
2
Type I Interferon: Monkeypox/Mpox Viruses Achilles Heel?Ⅰ型干扰素：猴痘/猴疱疹病毒的阿喀琉斯之踵？
Adv Exp Med Biol. 2024;1451:125-137. doi: 10.1007/978-3-031-57165-7_8.
3
Cross-species transmission and host range genes in poxviruses.痘病毒中的跨物种传播和宿主范围基因。
Virol Sin. 2024 Apr;39(2):177-193. doi: 10.1016/j.virs.2024.01.007. Epub 2024 Jan 23.
4
Orbivirus NS4 Proteins Play Multiple Roles to Dampen Cellular Responses.细环病毒 NS4 蛋白具有多种功能，可抑制细胞反应。
Viruses. 2023 Sep 12;15(9):1908. doi: 10.3390/v15091908.
5
Identification of Orbivirus Non-Structural Protein 5 (NS5), Its Role and Interaction with RNA/DNA in Infected Cells.鉴定呼肠孤病毒非结构蛋白 5（NS5）及其在感染细胞中与 RNA/DNA 的作用和相互作用。
Int J Mol Sci. 2023 Apr 6;24(7):6845. doi: 10.3390/ijms24076845.
6
How to Inhibit Nuclear Factor-Kappa B Signaling: Lessons from Poxviruses.如何抑制核因子-κB信号传导：来自痘病毒的经验教训
Pathogens. 2022 Sep 18;11(9):1061. doi: 10.3390/pathogens11091061.
7
Antagonism of Protein Kinase R by Large DNA Viruses.大型DNA病毒对蛋白激酶R的拮抗作用。
Pathogens. 2022 Jul 12;11(7):790. doi: 10.3390/pathogens11070790.
8
Small Hero with Great Powers: Vaccinia Virus E3 Protein and Evasion of the Type I IFN Response.拥有强大力量的小英雄：痘苗病毒E3蛋白与I型干扰素反应的逃避
Biomedicines. 2022 Jan 22;10(2):235. doi: 10.3390/biomedicines10020235.
9
Vaccinia virus E3 prevents sensing of Z-RNA to block ZBP1-dependent necroptosis.痘苗病毒 E3 阻止 Z-RNA 的感应来阻断 ZBP1 依赖的坏死性凋亡。
Cell Host Microbe. 2021 Aug 11;29(8):1266-1276.e5. doi: 10.1016/j.chom.2021.05.009. Epub 2021 Jun 29.
10
Subversion of Programed Cell Death by Poxviruses.痘病毒对细胞程序性死亡的抑制作用。
Curr Top Microbiol Immunol. 2023;442:105-131. doi: 10.1007/82_2020_229.

本文引用的文献

1
Genes of variola and vaccinia viruses necessary to overcome the host protective mechanisms.天花病毒和牛痘病毒中克服宿主保护机制所必需的基因。
FEBS Lett. 1993 Mar 15;319(1-2):80-3. doi: 10.1016/0014-5793(93)80041-r.
2
Nuclear localization of a double-stranded RNA-binding protein encoded by the vaccinia virus E3L gene.痘苗病毒E3L基因编码的双链RNA结合蛋白的核定位
Virology. 1993 Aug;195(2):732-44. doi: 10.1006/viro.1993.1424.
3
Recombinant vaccinia virus K3L gene product prevents activation of double-stranded RNA-dependent, initiation factor 2 alpha-specific protein kinase.重组痘苗病毒K3L基因产物可阻止双链RNA依赖性起始因子2α特异性蛋白激酶的激活。
J Biol Chem. 1993 Jun 15;268(17):12837-42.
4
Identification of a conserved motif that is necessary for binding of the vaccinia virus E3L gene products to double-stranded RNA.鉴定一种保守基序，该基序是痘苗病毒E3L基因产物与双链RNA结合所必需的。
Virology. 1993 Jun;194(2):537-47. doi: 10.1006/viro.1993.1292.
5
The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded RNA-dependent protein kinase by different mechanisms.E3L和K3L痘苗病毒基因产物通过不同机制抑制双链RNA依赖性蛋白激酶来刺激翻译。
J Virol. 1993 Mar;67(3):1688-92. doi: 10.1128/JVI.67.3.1688-1692.1993.
6
The mouse antiphosphotyrosine immunoreactive kinase, TIK, is indistinguishable from the double-stranded RNA-dependent, interferon-induced protein kinase, PKR.小鼠抗磷酸酪氨酸免疫反应性激酶TIK与双链RNA依赖性干扰素诱导蛋白激酶PKR无法区分。
Nucleic Acids Res. 1993 Oct 11;21(20):4830-5. doi: 10.1093/nar/21.20.4830.
7
Reversal of the interferon-sensitive phenotype of a vaccinia virus lacking E3L by expression of the reovirus S4 gene.通过呼肠孤病毒S4基因的表达逆转缺乏E3L的痘苗病毒的干扰素敏感表型。
J Virol. 1995 Jan;69(1):499-505. doi: 10.1128/JVI.69.1.499-505.1995.
8
TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR.TAR RNA结合蛋白是干扰素诱导蛋白激酶PKR的一种抑制剂。
Proc Natl Acad Sci U S A. 1994 May 24;91(11):4713-7. doi: 10.1073/pnas.91.11.4713.
9
Products of the porcine group C rotavirus NSP3 gene bind specifically to double-stranded RNA and inhibit activation of the interferon-induced protein kinase PKR.猪C组轮状病毒NSP3基因产物特异性结合双链RNA并抑制干扰素诱导蛋白激酶PKR的激活。
J Virol. 1994 Jun;68(6):3821-9. doi: 10.1128/JVI.68.6.3821-3829.1994.
10
Vaccinia rescue of VSV from interferon-induced resistance: reversal of translation block and inhibition of protein kinase activity.痘苗病毒从干扰素诱导的抗性中拯救水疱性口炎病毒：翻译阻断的逆转和蛋白激酶活性的抑制
Virology. 1983 Nov;131(1):128-36. doi: 10.1016/0042-6822(83)90539-1.

通过E3L突变体拯救缺失E3L基因的痘苗病毒。

Rescue of vaccinia virus lacking the E3L gene by mutants of E3L.

作者信息

Chang H W, Uribe L H, Jacobs B L

机构信息

Department of Microbiology, Arizona State University, Tempe 85287-2701, USA.

出版信息

J Virol. 1995 Oct;69(10):6605-8. doi: 10.1128/JVI.69.10.6605-6608.1995.

DOI:10.1128/JVI.69.10.6605-6608.1995
PMID:7666567
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC189568/
Abstract

Vaccinia virus with the E3L gene deleted was able to replicate in RK-13 but not HeLa cells. This host range phenotype could be complemented by an E3L gene expressed transiently from a plasmid. Analysis of mutants of E3L indicates that the ability to complement deletion of E3L correlates with the ability of mutated proteins to bind double-stranded RNA but not with their ability to migrate to the nucleus.

摘要

缺失E3L基因的痘苗病毒能够在RK - 13细胞中复制，但不能在HeLa细胞中复制。这种宿主范围表型可以通过从质粒瞬时表达的E3L基因来互补。对E3L突变体的分析表明，互补E3L缺失的能力与突变蛋白结合双链RNA的能力相关，而与其迁移到细胞核的能力无关。