Rakarić-Poznanović M, Snur I, Ranić V, Sabljić T
Klinika za traumatologiju, Zagreb.
Lijec Vjesn. 1995 Jun;117 Suppl 2:107-9.
The acute phase response after severe trauma leads to the major changes in synthesis and levels of plasma proteins. Activation of humoral cascade system and activity of phagocytes accelerates healing. In the prospective study the levels of serum total proteins and albumin in relation to acute phase proteins, fibrinogen and CRP were measured in the group of 34 severe traumatized patients, age 31.21 +/- 1.52 yrs submitted to the standardized ICU treatment. An increase in the levels of serum total protein from 51.07 to 52.53 g/l was registered during the first week. The levels of albumin were below 30 g/l for most of the patients during the entire two-week examination. The initial levels of albumin were 26.40 +/- 6.13 g/l and at the end of the examination 29.60 +/- 2.97 g/l (p = 0.008). The levels of fibrinogen showed the increase to 5.93 g/l during the entire examination. The rapid increase in the levels of CRP from 5 mg/l to 169.67 mg/l 48 hours after trauma and were still high at the end of examination 45 mg/l. That implies the activity of inflammatory mediators. The role and supplement of certain amino acids in maintaining the integrity of intestinal mucosa and immune system during the acute response to stress is discussed.
严重创伤后的急性期反应会导致血浆蛋白合成和水平发生重大变化。体液级联系统的激活和吞噬细胞的活性会加速愈合。在这项前瞻性研究中，对34名年龄为31.21±1.52岁、接受标准化重症监护病房治疗的严重创伤患者进行了血清总蛋白和白蛋白水平与急性期蛋白、纤维蛋白原和CRP的相关性检测。在第一周内，血清总蛋白水平从51.07克/升升至52.53克/升。在整个两周的检查期间，大多数患者的白蛋白水平低于30克/升。白蛋白初始水平为26.40±6.13克/升，检查结束时为29.60±2.97克/升（p = 0.008）。在整个检查期间，纤维蛋白原水平升至5.93克/升。创伤后48小时，CRP水平从5毫克/升迅速升至169.67毫克/升，检查结束时仍高达45毫克/升。这意味着炎症介质的活性。文中讨论了某些氨基酸在应激急性期维持肠黏膜完整性和免疫系统中的作用及补充情况。
