Hall M, Whaley R, Robertson K, Hamby S, Wilkins J, Hall C
AIDS Neurologic Center, University of North Carolina School of Medicine, Chapel Hill 27599, USA.
Neurology. 1996 Jun;46(6):1697-702. doi: 10.1212/wnl.46.6.1697.
To determine the relationship between neuroanatomic and neuropsychological changes in both asymptomatic and symptomatic HIV-1-infected individuals, we conducted a longitudinal study of 47 HIV-infected individuals, 15 of whom were asymptomatic and 32 of whom had either AIDS-related complex or AIDS. To measure neuroanatomic change over a 30-month period, we conducted quantitative MRI measures of bicaudate/brain ratio (BCR) and bifrontal/ brain ratio. A comparison of change over time between BCR and neuropsychological performance showed a correlation between increase in atrophy and worsening in certain cognitive functions. The correlation held for both asymptomatic and symptomatic groups, with more pronounced changes in the symptomatic group.
为了确定无症状和有症状的HIV-1感染者神经解剖学和神经心理学变化之间的关系，我们对47名HIV感染者进行了一项纵向研究，其中15人无症状，32人患有艾滋病相关综合征或艾滋病。为了测量30个月期间的神经解剖学变化，我们对双侧尾状核/脑比率（BCR）和双侧额叶/脑比率进行了定量MRI测量。BCR变化与神经心理学表现随时间的比较显示，萎缩增加与某些认知功能恶化之间存在相关性。这种相关性在无症状和有症状组中均成立，有症状组的变化更为明显。
