Bellows J G, Bellows R T
Klin Monbl Augenheilkd. 1977 Mar;170(3):379-87.
The traditional theories of senile cataract formation have one common denominator. Nearly all the agents and factors heretofore ascribed as causes of cataract formation have some element involving a potent crosslinking agent. The factors considered in this paper include endocrine and metabolic factors, involutional and hereditary influences, nutritional deficiencies, osmotic changes, ionizing radiation, ultraviolet light, altered capsular permeability, and the cumulative effects of subliminal exposure to noxae. Throughout life, the human lens is exposed to the influence of numerous potent crosslinking agents and it now appears that the cumulative actions of crosslinkage is the chief cause of senile cataracts. If this theory proves to be correct, it will offer some hope that cataract formation can be retarded by agents which counteract crosslinkage or by avoidance of excessive exposure to crosslinking agents.
传统的老年性白内障形成理论有一个共同特点。迄今为止，几乎所有被认为是白内障形成原因的因素和因子都有某种涉及强力交联剂的成分。本文所考虑的因素包括内分泌和代谢因素、退行性和遗传影响、营养缺乏、渗透压变化、电离辐射、紫外线、晶状体囊膜通透性改变以及对有害物质的阈下暴露的累积效应。在整个生命过程中，人眼晶状体都会受到多种强力交联剂的影响，现在看来，交联的累积作用是老年性白内障的主要成因。如果这一理论被证明是正确的，那么就有望通过抵消交联作用的药物或避免过度暴露于交联剂来延缓白内障的形成。
