Ishigooka M, Hashimoto T, Hayami S, Suzuki Y, Sasagawa I, Nakada T
Department of Urology, Yamagata University, School of Medicine, Japan.
Prostate. 1996 Jun;28(6):385-91. doi: 10.1002/(SICI)1097-0045(199606)28:6<385::AID-PROS8>3.0.CO;2-9.
Tissue norepinephrine (NE) content and quantitative morphometric analysis of benign prostatic hyperplasia (BPH) were evaluated in 30 patients with symptomatic BPH. BPH specimens were obtained by transurethral resection, and NE content was evaluated by high-performance liquid chromatography. The proportions of smooth muscle fibrous, and glandular elements were determined by the light microscopic stereological method. Norepinephrine content of the prostate correlated well with the proportion of smooth muscle component (r = 0.749, P < 0.0001). The percentage of fibrous tissue element was positively correlated with prostate size (r = 0.459, P = 0.0099). Norepinephrine content and histological components did not correlate with subjective symptom score. Morphometrical findings and NE content did not correlate with uroflowmetry parameters and postvoid residual urine rate. In conclusion, NE content of the prostate was probably determined by the amount of smooth muscle element in BPH tissue. The fibrous tissue element was increased in large hyperplastic tissue. The severity of BPH could not be explained by differences in histological composition alone.
对30例有症状的良性前列腺增生（BPH）患者的组织去甲肾上腺素（NE）含量及BPH进行定量形态学分析。通过经尿道切除术获取BPH标本，采用高效液相色谱法评估NE含量。通过光学显微镜体视学方法确定平滑肌、纤维和腺性成分的比例。前列腺的去甲肾上腺素含量与平滑肌成分比例密切相关（r = 0.749，P < 0.0001）。纤维组织成分的百分比与前列腺大小呈正相关（r = 0.459，P = 0.0099）。去甲肾上腺素含量和组织学成分与主观症状评分无关。形态学结果和NE含量与尿流率参数及排尿后残余尿量率无关。总之，前列腺的NE含量可能由BPH组织中平滑肌成分的数量决定。大型增生组织中纤维组织成分增加。仅靠组织学组成的差异无法解释BPH的严重程度。
