Ishigooka M, Hayami S, Hashimoto T, Suzuki Y, Katoh T, Nakada T
Department of Urology, Yamagata University, School of Medicine, Japan.
Prostate. 1996 Aug;29(2):77-82. doi: 10.1002/(SICI)1097-0045(199608)29:2<77::AID-PROS2>3.0.CO;2-E.
To investigate the correlation between histological differences and clinical findings in patients with benign prostatic hyperplasia (BPH), quantitative morphometrical analysis on prostate was performed on 26 specimens obtained by TURP. The relative and total volume of each histological component were obtained. In this series, the proportion of fibrous tissue element showed a weak positive correlation with prostatic volume (r = 0.499, P = 0.0087). The relative volume of the smooth muscle component showed an inverse correlation with prostatic volume (r = -0.488, P = 0.0105). Patient age and symptom score showed no relationship with the relative volume of histological components. The total volume of all histological components increased with prostatic volume. However, an increase in the fibrous tissue element appeared to be predominant in prostatic enlargement (r = 0.970, P < 0.0001). Although the total volume of all histological components increased with prostatic size, fibrous tissue appeared to play a major role in prostatic enlargement in BPH.
为研究良性前列腺增生（BPH）患者组织学差异与临床发现之间的相关性，对经尿道前列腺切除术（TURP）获取的26份前列腺标本进行了定量形态计量分析。得出了各组织学成分的相对体积和总体积。在该系列研究中，纤维组织成分的比例与前列腺体积呈弱正相关（r = 0.499，P = 0.0087）。平滑肌成分的相对体积与前列腺体积呈负相关（r = -0.488，P = 0.0105）。患者年龄和症状评分与组织学成分的相对体积无关。所有组织学成分的总体积随前列腺体积增加而增加。然而，纤维组织成分的增加在前列腺增大中似乎占主导地位（r = 0.970，P < 0.0001）。尽管所有组织学成分的总体积随前列腺大小增加而增加，但在BPH患者的前列腺增大中，纤维组织似乎起主要作用。
