Karin M
Department of Pharmacology, University of California, San Diego School of Medicine, La Jolla 92093, USA.
Philos Trans R Soc Lond B Biol Sci. 1996 Feb 29;351(1336):127-34. doi: 10.1098/rstb.1996.0008.
AP-1 is a collection of dimeric sequence specific, DNA binding, transcriptional activators composed of Jun and Fos subunits. The composition, the level and the activity of AP-1 complexes are regulated in response to extracellular stimuli. An important role in this regulation is played by mitogen-activated protein kinases (MAPKs). The specific roles of three MAPKs, namely ERK, JNK and FRK, in modulation of both the level and activity of AP-1, are discussed.
AP-1是由Jun和Fos亚基组成的二聚体序列特异性DNA结合转录激活因子的集合。AP-1复合物的组成、水平和活性会根据细胞外刺激进行调节。丝裂原活化蛋白激酶（MAPK）在这种调节中发挥重要作用。本文讨论了三种MAPK，即细胞外信号调节激酶（ERK）、应激活化蛋白激酶（JNK）和FRK，在调节AP-1水平和活性方面的具体作用。
