Virag R, Bachir D, Lee K, Galacteros F
Centre d'Explorations et de Traitements de l'Impuissance, Paris, France.
Urology. 1996 May;47(5):777-81; discussion 781. doi: 10.1016/s0090-4295(96)00027-1.
Priapism is a common and currently unsatisfactorily managed complication of sickle cell disease (SCD). In June 1994, 6 SCD patients received a new therapeutic regimen to prevent the occurrence and recurrence of priapism.
The patients (5 with SS and 1 with SC) were adults and had frequent episodes of stuttering priapism (SP), and two of them had had acute episodes (AP) lasting more than 3 hours. The treatment consists of preventive oral administration of the alpha-adrenergic agent etilefrine, and self-administered intracavernous injection (SICI) of the same agent to reverse episodes lasting more than 1 hour.
Since the beginning of treatment, all patients were protected against AP, 4 patients had no recurrence with the oral treatment alone, 2 had to use SICI, 1 occasionally and 1 constantly. There was no modification of sexual activity and no complications. Blood pressure was unaffected.
This treatment is simple, cheap, and self-administered. It should be proposed to all patients with SCD in all geographic areas as part of an educational program for active prevention of this severe complication.
阴茎异常勃起是镰状细胞病（SCD）常见且目前治疗效果不尽人意的一种并发症。1994年6月，6例SCD患者接受了一种新的治疗方案以预防阴茎异常勃起的发生和复发。
这些患者（5例SS型和1例SC型）均为成年人，频繁出现间歇性阴茎异常勃起（SP），其中2例曾有持续超过3小时的急性阴茎异常勃起（AP）发作。治疗包括预防性口服α-肾上腺素能药物乙苯福林，以及自行海绵体内注射（SICI）同一药物以逆转持续超过1小时的发作。
自治疗开始以来，所有患者均未发生AP，4例患者仅通过口服治疗未再复发，2例患者需使用SICI，1例偶尔使用，1例持续使用。性功能未受影响，也未出现并发症。血压未受影响。
这种治疗方法简单、便宜且可自行实施。作为积极预防这种严重并发症的教育项目的一部分，应向所有地区的所有SCD患者推荐该治疗方法。
