Mihm S, Hartmann H, Fayyazi A, Ramadori G
Department of Internal Medicine, Georg-August-Universität, Göttingen, Germany.
Dig Dis Sci. 1996 Jun;41(6):1256-64. doi: 10.1007/BF02088246.
Hepatitis C virus infection causes acute and often chronic hepatitis. Therapy with interferon-alpha has been shown to induce remission of the inflammatory process within the liver and also elimination of the virus. However, only about 50% of treated patients respond in terms of at least a transient disappearance of viral RNA from the circulation below the limit of detection. In order to find prognostic factors for responsiveness, patients with chronic hepatitis C virus infection were analyzed for virus genotype and pretreatment biochemical liver parameters including serum AST, ALT, and gamma-GT activities. Whereas the initial biochemical response to interferon-alpha 2a was found not to be related to virus genotype, the initial virological response was found to be closely related to infection by genotype 3a and to a low pretreatment ratio of serum gamma-GT/ALT activity. These data confirm and extend the importance of virus genotype for responsiveness to interferon-alpha therapy and introduce an additional, host-specific parameter with a potential predictive value, namely the pretreatment ratio of serum gamma-GT/ALT activity.
丙型肝炎病毒感染会引发急性肝炎，且常常导致慢性肝炎。已证实，使用α干扰素进行治疗可促使肝脏内的炎症过程缓解，还能清除病毒。然而，在接受治疗的患者中，只有约50%的患者至少在短期内出现循环中的病毒RNA降至检测限以下的情况。为了找出反应性的预后因素，对慢性丙型肝炎病毒感染患者进行了病毒基因型以及包括血清AST、ALT和γ-GT活性在内的治疗前生化肝脏参数分析。虽然发现对α干扰素2a的初始生化反应与病毒基因型无关，但发现初始病毒学反应与3a基因型感染以及治疗前血清γ-GT/ALT活性比值较低密切相关。这些数据证实并扩展了病毒基因型对α干扰素治疗反应性的重要性，并引入了另一个具有潜在预测价值的宿主特异性参数，即血清γ-GT/ALT活性的治疗前比值。
