Di Mascio R, Marchioli R, Vitullo F, Tognoni G
Laboratory of Clinical Pharmacology, Consorzio Mario Negri Sud, Chieti, Italy.
Eur Neurol. 1996;36(2):85-8. doi: 10.1159/000117214.
We examined the relationship between the hemoglobin concentration and the risk of ischemic stroke using data from a hospital-based case-control study. A total of 143 patients (age 30-69 years) with a diagnosis of cerebral infarction confirmed by computerized tomography scan and 143 age- and sex-matched controls entered the study. Hemoglobin was higher in the patients with stroke (14.2 +/- 1.6 g/l, mean +/- SD) than in controls (13.7 +/- 1.6 g/l; p < 0.05). Compared with subjects with hemoglobin levels of less than 13 g/l (reference category), the relative risk of ischemic stroke, after allowance for potential risk factors, was 2.0 (95% CI 0.8-4.9) for the 13-13.9 g/l quartile, 2.8 (95% CI 1.2-6.5) for the 14-14.9 g/l quartile, and 3.2 (95% CI 1.4-7.4) for the 14 + g/l quartile (chi 2 for linear trend 7.27, p < 0.01). We conclude that the hemoglobin concentration may be an indicator of risk for ischemic stroke.
我们利用一项基于医院的病例对照研究的数据，研究了血红蛋白浓度与缺血性中风风险之间的关系。共有143例经计算机断层扫描确诊为脑梗死的患者（年龄30 - 69岁）和143例年龄及性别匹配的对照者纳入本研究。中风患者的血红蛋白水平（14.2 +/- 1.6 g/l，均值 +/- 标准差）高于对照组（13.7 +/- 1.6 g/l；p < 0.05）。与血红蛋白水平低于13 g/l的受试者（参照类别）相比，在考虑潜在风险因素后，血红蛋白水平处于13 - 13.9 g/l四分位数区间的受试者发生缺血性中风的相对风险为2.0（95%可信区间0.8 - 4.9），14 - 14.9 g/l四分位数区间为2.8（95%可信区间1.2 - 6.5），14 + g/l四分位数区间为3.2（95%可信区间1.4 - 7.4）（线性趋势的卡方值为7.27，p < 0.01）。我们得出结论，血红蛋白浓度可能是缺血性中风风险的一个指标。
