内毒素对脂质代谢的影响。
Effects of endotoxin on lipid metabolism.
作者信息
Hardardóttir I, Grunfeld C, Feingold K R
机构信息
Department of Medicine, University of California San Francisco, USA.
出版信息
Biochem Soc Trans. 1995 Nov;23(4):1013-8. doi: 10.1042/bst0231013.
Endotoxin, via cytokines, induces marked changes in lipid metabolism which are now considered part of the acute phase response. The endotoxin induced hyperlipidemia may represent a nonspecific immune response that can decrease the toxicity of a variety of harmful biological and chemical agents and serve to redistribute nutrients to cells important in host defense. The endotoxin induced changes in lipid metabolism may therefore be beneficial.
内毒素通过细胞因子诱导脂质代谢发生显著变化，目前这些变化被认为是急性期反应的一部分。内毒素诱导的高脂血症可能代表一种非特异性免疫反应，它可以降低多种有害生物和化学物质的毒性，并有助于将营养物质重新分配到对宿主防御至关重要的细胞中。因此，内毒素诱导的脂质代谢变化可能是有益的。
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