HIV感染患者肝活检后致命性出血
Fatal haemorrhage following liver biopsy in patients with HIV infection.
作者信息
Churchill D R, Mann D, Coker R J, Miller R F, Glazer G, Goldin R D, Lucas S B, Weber J N, De Cock K M
机构信息
Department of Genitourinary Medicine, Communicable Diseases, St Mary's Hospital and Medical School, London.
出版信息
Genitourin Med. 1996 Feb;72(1):62-4. doi: 10.1136/sti.72.1.62.
A retrospective review of all 248 liver biopsies performed in patients with HIV infection at two referral centres in London over a 12 year period revealed five cases of major bleeding following biopsy, with four deaths. The risk of major bleeding was 2.0%, and mortality was 1.6% following liver biopsy. The risk of bleeding as much higher than in published series of biopsies done in patients without HIV infection, owing in part to the high prevalence of thrombocytopaenia and clotting abnormalities in patients with HIV infection. HIV infection per se may also increase the risk of bleeding following liver biopsy.
对伦敦两个转诊中心12年间对248例HIV感染患者进行的肝脏活检进行回顾性分析发现，活检后发生大出血5例，死亡4例。肝脏活检后大出血风险为2.0%，死亡率为1.6%。出血风险远高于已发表的非HIV感染患者活检系列报道，部分原因是HIV感染患者血小板减少和凝血异常的发生率较高。HIV感染本身也可能增加肝脏活检后的出血风险。
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