通过基于DNA的基因分型方法证实获得性B血型表型中不存在B等位基因。
The absence of a B allele in acquired B blood group phenotype confirmed by a DNA based genotyping method.
作者信息
Yip S P, Choy W L, Chan C W, Choi C H
机构信息
Department of Health Science, Hong Kong Polytechnic University, Kowloon.
出版信息
J Clin Pathol. 1996 Feb;49(2):180-1. doi: 10.1136/jcp.49.2.180.
Abstract
A case of an 87 year old woman with carcinomatous sigmoid colon, found to be of group A1 with acquired B status, is reported. The acquired B phenotype was confirmed by the absence of a B allele in the patient using denaturing gradient gel electrophoresis of a DNA fragment amplified from the ABO locus by the polymerase chain reaction.
摘要
报告了一例87岁患有乙状结肠癌的女性病例，发现其血型为A1且具有获得性B抗原。通过聚合酶链反应从ABO基因座扩增DNA片段，采用变性梯度凝胶电泳法检测患者体内不存在B等位基因，从而证实了这种获得性B血型表型。
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本文引用的文献
1
DNA polymorphism at the ABO locus in the Chinese population of Hong Kong.中国香港人群ABO基因座的DNA多态性
Hum Hered. 1995 Sep-Oct;45(5):266-71. doi: 10.1159/000154311.
2
Molecular genetic basis of the histo-blood group ABO system.组织血型ABO系统的分子遗传基础。
Nature. 1990 May 17;345(6272):229-33. doi: 10.1038/345229a0.
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