Pelletier G, Raymond J M, Capdeville R, Mosnier H, Caroli-Bosc F X
Hôpital de Bicêtre, Le Kremlin Bicêtre, France.
J Hepatol. 1995 Oct;23(4):420-3. doi: 10.1016/0168-8278(95)80200-2.
We report the recurrence rate of gallstone within 5 years after successful lithotripsy. One hundred and fifty consecutive patients (solitary stones, 102 patients; multiple stones, 48 patients) were followed up for a median of 42 months (range 6-72) after stone clearance and cessation of bile acid therapy. No patient received any therapy to prevent recurrence. Thirty-seven patients developed recurrent gallstones. Probabilities of recurrence were (mean +/- SD) 6.6% +/- 2%, 15.7% +/- 3%, 22.8% +/- 3.6%, 29.7% +/- 4.5%, 32.2% +/- 5% at 1, 2, 3, 4 and 5 years, respectively. The recurrence rate was lower in patients who had solitary stones than in patients with multiple stones (26.1% versus 47% at 5 years, respectively; p<0.009 - log rank test). Only five patients developed recurrent symptoms or stone complication (14%). We conclude that the recurrence rate after successful lithotripsy is lower than expected from dissolution studies, due to a low recurrence rate in patients who had solitary stones.
我们报告了碎石成功后5年内胆结石的复发率。150例连续患者（单发结石102例；多发结石48例）在结石清除且停止胆汁酸治疗后接受了中位时间为42个月（范围6 - 72个月）的随访。没有患者接受任何预防复发的治疗。37例患者出现复发性胆结石。1年、2年、3年、4年和5年的复发概率分别为（均值±标准差）6.6%±2%、15.7%±3%、22.8%±3.6%、29.7%±4.5%、32.2%±5%。单发结石患者的复发率低于多发结石患者（5年时分别为26.1%和47%；p<0.009 - 对数秩检验）。只有5例患者出现复发症状或结石并发症（14%）。我们得出结论，由于单发结石患者的复发率较低，碎石成功后的复发率低于溶解研究预期。
