Tsolaki A G, Miller R F, Underwood A P, Banerji S, Wakefield A E
Department of Paediatrics, John Radcliffe Hospital, Oxford, United Kingdom.
J Infect Dis. 1996 Jul;174(1):141-56. doi: 10.1093/infdis/174.1.141.
The opportunistic fungal pathogen Pneumocystis carinii sp. f. hominis is a frequent cause of pneumonia in the immunocompromised host. Analysis of genetic variation among isolates of P. carinii sp. f. hominis from 12 human immunodeficiency virus (HIV)-infected persons with single and multiple episodes of P. carinii pneumonia was undertaken at the internal transcribed spacer (ITS) regions of the nuclear rRNA operon. In samples from 24 episodes of pneumonia, 10 different types of P. carinii sp. f. hominis were identified. More than 1 sequence type was observed in 8 samples, indicating that mixed infection with different types of P. carinii sp. f. hominis is not uncommon. In 4 of 7 patients with recurrent episodes of pneumonia, the sequence types observed at the second episode were different from those of the first, suggesting the occurrence of both reactivation of a previously acquired infection and reinfection from an exogenous source.
机会性真菌病原体卡氏肺孢子菌人型变种是免疫功能低下宿主肺炎的常见病因。对来自12例患有卡氏肺孢子菌肺炎单发和多发发作的人类免疫缺陷病毒（HIV）感染者的卡氏肺孢子菌人型变种分离株的核rRNA操纵子内部转录间隔区（ITS）进行了遗传变异分析。在24例肺炎样本中，鉴定出10种不同类型的卡氏肺孢子菌人型变种。在8个样本中观察到不止1种序列类型，表明不同类型的卡氏肺孢子菌人型变种混合感染并不罕见。在7例复发性肺炎患者中的4例中，第二次发作时观察到的序列类型与第一次不同，提示先前获得的感染重新激活以及外源性再感染均有发生。
