Olveda R M, Daniel B L, Ramirez B D, Aligui G D, Acosta L P, Fevidal P, Tiu E, de Veyra F, Peters P A, Romulo R, Domingo E, Wiest P M, Olds G R
Department of Health, University of the Philippines, College of Medicine, Manila, Philippines.
J Infect Dis. 1996 Jul;174(1):163-72. doi: 10.1093/infdis/174.1.163.
The long-term impact of annual case-finding and chemotherapy with praziquantel on schistosomiasis japonica was examined in an 8-year longitudinal study in the Philippines. The prevalence, incidence, and intensity of infection and schistosome-induced hepatomegaly significantly decreased within 3-4 years of treatment and then stabilized despite continual population-based chemotherapy. Hepatomegaly rapidly developed in acutely infected persons, with 82% of subjects developing hepatic enlargement within 2 years of reinfection. These data suggest that abrupt discontinuation of current control measures in the Philippines may result in a rapid rebound in morbidity. Age-dependent acquired resistance to reinfection also developed in subjects chronically exposed to schistosomiasis japonica, suggesting that a vaccine may represent an alternative approach for control of this parasitic infection.
在菲律宾进行的一项为期8年的纵向研究中，考察了采用吡喹酮进行年度病例发现和化疗对日本血吸虫病的长期影响。治疗后3至4年内，感染率、发病率、感染强度以及血吸虫引起的肝肿大均显著下降，之后尽管持续进行基于人群的化疗，但这些指标趋于稳定。急性感染者肝肿大迅速发展，82%的受试者在再次感染后2年内出现肝脏肿大。这些数据表明，菲律宾目前的控制措施若突然中断，可能导致发病率迅速反弹。长期接触日本血吸虫病的受试者还产生了年龄依赖性的再感染获得性抗性，这表明疫苗可能是控制这种寄生虫感染的另一种方法。
