Tanaka H, Blas B L, Noseñas J S, Matsuda H, Hayashi Y, Santos A T
Jpn J Exp Med. 1985 Aug;55(4):161-5.
The effect of selective mass-chemotherapy with praziquantel at a dose of 60 mg/kg a day on the annual incidence of Schistosoma japonicum infection was examined by a follow-up study of 1,800 school children enrolled at 9 primary schools at Dagami Area, Leyte, Philippines. The incidence rates before mass-chemotherapy were 22.2, 24.2, 26.9, 9.6 and 28.4% in a period from school year (SY) 1975/76 to 1979/80, respectively, where the incidence of 9.6% in SY 1978/79 was probably due to extraordinary drought in the previous year. Egg positives including village people were treated and the numbers treated yearly were 22, 943, 273, 300 and 341 from SY 1978/79 to SY 1982/83, respectively. The incidence was reduced drastically as early as one year following the start of mass-chemotherapy, i.e., 8.4, no survey, 6.8 and 15.4%, from SY 1980/81 to SY 1983/84, respectively, and which demonstrated the efficacy of mass-chemotherapy on reduction of transmission.
通过对菲律宾莱特省达加米地区9所小学的1800名在校儿童进行随访研究，考察了每日服用60mg/kg吡喹酮进行选择性群体化疗对日本血吸虫感染年发病率的影响。在1975/76学年至1979/80学年期间，群体化疗前的发病率分别为22.2%、24.2%、26.9%、9.6%和28.4%，其中1978/79学年9.6%的发病率可能是由于上一年的特大干旱。包括村民在内的粪便阳性者均接受了治疗，从1978/79学年到1982/83学年，每年接受治疗的人数分别为22、943、273、300和341人。群体化疗开始后仅一年，发病率就大幅下降，即从1980/81学年到1983/84学年，发病率分别为8.4%、无调查、6.8%和15.4%，这表明群体化疗对减少传播具有疗效。
