Rehg J E
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
J Infect Dis. 1996 Jul;174(1):229-32. doi: 10.1093/infdis/174.1.229.
The activity of recombinant murine interferon-gamma (IFN-gamma) against infection by Cryptosporidium parvum was evaluated in immunosuppressed rats. Daily intraperitoneal doses of at least 125,000 U/kg significantly (P < .05) reduced the intensity of subsequent ileal infection. In addition, daily administration of 500,000 U/kg significantly (P < .05) inhibited colonization of the biliary tract. When administered for 11 days to rats with established C. parvum infection, IFN-gamma significantly (P < .05) reduced the number of parasites in the small intestine, but this treatment was ineffective against infection of the biliary tract and large intestine. Although the parasite loads in the common bile duct and large intestine were not significantly reduced, there were fewer cases of infection among the treated rats than in the control group. The data suggest that treatment with IFN-gamma may limit cryptosporidiosis of the small intestine.
在免疫抑制大鼠中评估了重组鼠γ干扰素（IFN-γ）抗微小隐孢子虫感染的活性。每日腹腔注射剂量至少为125,000 U/kg时，可显著（P <.05）降低随后回肠感染的强度。此外，每日给予500,000 U/kg可显著（P <.05）抑制胆道定植。当对已建立微小隐孢子虫感染的大鼠给药11天时，IFN-γ可显著（P <.05）减少小肠中的寄生虫数量，但这种治疗对胆道和大肠感染无效。尽管胆总管和大肠中的寄生虫负荷没有显著降低，但治疗组大鼠的感染病例比对照组少。数据表明，用IFN-γ治疗可能会限制小肠隐孢子虫病。
