Zetterström C, Kugelberg U, Lundgren B, Syrén-Nordqvist S
Department of Ophthalmology, S:t Erik Eye Hospital, Stockholm, Sweden.
J Cataract Refract Surg. 1996 Jan-Feb;22(1):85-8. doi: 10.1016/s0886-3350(96)80275-6.
Comparison of the after-cataract formation in newborn rabbits implanted with a heparin-surface-modified (HSM) intraocular lens (IOL), a silicone IOL, or no IOL.
Two groups of 3-week-old rabbits were used. In Group 1 (n = 11), lensectomy was performed in both eyes. One eye was selected at random and an HSM IOL was implanted in the capsular bag; the other eye was left aphakic. In Group 2 (n = 13), lensectomy was performed in both eyes. An HSM IOL was implanted in one eye, a silicone IOL in the other. The wet mass of the dissected after-cataract was determined 3 months after surgery in both groups.
In Group 1, the wet mass of the dissected after-cataract was 17.0 +/- 6.5 mg (mean +/- SEM) in eyes implanted with an HSM IOL and 159.7 +/- 17.0 mg in aphakic eyes. This difference was statistically significant (P < .01). In Group 2, the wet mass of the dissected after-cataract was 18.3 +/- 4.3 mg in eyes implanted with an HSM IOL and 25.7 +/- 5.2 mg in eyes implanted with a silicone IOL. No statistically significant difference was found.
In young rabbits, implantation of an IOL in the capsular bag following lensectomy reduced cell proliferation.
