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本文引用的文献

1
Lens epithelial cell migration onto the posterior capsule in vitro.
J Cataract Refract Surg. 1996;22 Suppl 1:841-6. doi: 10.1016/s0886-3350(96)80172-6.
2
Intraocular folding of an acrylic lens for explantation through a small incision cataract wound.
J Cataract Refract Surg. 1996;22 Suppl 2:1383-6. doi: 10.1016/s0886-3350(96)80104-0.
3
Bisecting a foldable acrylic intraocular lens for explantation.
J Cataract Refract Surg. 1996;22 Suppl 2:1381-2. doi: 10.1016/s0886-3350(96)80103-9.
4
Evaluation of the first 50 ACR360 acrylic intraocular lens implantations.
J Cataract Refract Surg. 1996;22 Suppl 2:1373-8. doi: 10.1016/s0886-3350(96)80101-5.
5
Neodymium: YAG capsulotomy rates after phacoemulsification with silicone posterior chamber intraocular lenses.使用硅酮后房型人工晶状体进行白内障超声乳化吸除术后钕：钇铝石榴石晶状体囊切开术的发生率
J Cataract Refract Surg. 1996;22 Suppl 2:1296-302. doi: 10.1016/s0886-3350(96)80088-5.
6
Capsular capture of silicone intraocular lenses.
J Cataract Refract Surg. 1996;22 Suppl 2:1267-71. doi: 10.1016/s0886-3350(96)80082-4.
7
After-cataract formation in newborn rabbits implanted with intraocular lenses.
J Cataract Refract Surg. 1996 Jan-Feb;22(1):85-8. doi: 10.1016/s0886-3350(96)80275-6.
8
Two year clinical study of a soft acrylic intraocular lens.软性丙烯酸酯人工晶状体的两年临床研究
J Cataract Refract Surg. 1996 Jan-Feb;22(1):104-9. doi: 10.1016/s0886-3350(96)80278-1.
9
Effect of intraocular lens design on posterior capsule opacification after continuous curvilinear capsulorhexis.
J Cataract Refract Surg. 1995 Nov;21(6):697-700. doi: 10.1016/s0886-3350(13)80569-x.
10
Restoring lens capsule integrity enhances lens regeneration in New Zealand albino rabbits and cats.恢复晶状体囊膜完整性可促进新西兰白化兔和猫的晶状体再生。
J Cataract Refract Surg. 1993 Nov;19(6):735-46. doi: 10.1016/s0886-3350(13)80343-4.

晶状体囊膜与聚甲基丙烯酸甲酯、硅酮和丙烯酸可折叠材料人工晶状体的粘连：一项实验研究。

Adhesion of lens capsule to intraocular lenses of polymethylmethacrylate, silicone, and acrylic foldable materials: an experimental study.

作者信息

Oshika T, Nagata T, Ishii Y

机构信息

Department of Ophthalmology, University of Tokyo School of Medicine, Japan.

出版信息

Br J Ophthalmol. 1998 May;82(5):549-53. doi: 10.1136/bjo.82.5.549.

DOI:10.1136/bjo.82.5.549
PMID:9713064
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1722579/
Abstract

AIMS

To investigate the adhesion characteristics of several intraocular lenses (IOLs) to the simulated and rabbit lens capsule.

METHODS

Adhesive force to bovine collagen sheets was measured in water with polymethylmethacrylate (PMMA), three piece silicone, and acrylic foldable IOLs. In rabbit eyes, phacoemulsification and IOL implantation were performed. Three weeks later, adhesion between the anterior/posterior capsules and IOL optic was tested, and the capsule was examined histologically.

RESULTS

The mean adhesive force to the collagen sheet was 1697 (SD 286) mg for acrylic foldable, 583 (49) mg for PMMA, and 0 mg for silicone IOLs (p = 0.0003, Kruskal-Wallis test). Scores (0-5) of adhesion between rabbit anterior capsule and IOL optic were 4.50 (0.55) for acrylic foldable, 3.20 (0.84) for PMMA, and 0.40 (0.55) for silicone IOLs (p = 0.004). Scores between rabbit posterior capsule and IOL optic displayed a similar tendency; 4.50 (0.84) for acrylic foldable, 3.00 (1.00) for PMMA, and 0.40 (0.55) for silicone IOLs (p = 0.021). Histological observation indicated that the edge of IOL optic suppressed the migration of lens epithelial cells towards the centre of the posterior capsule. This inhibitory effect was most pronounced with acrylic foldable IOL and least with silicone IOL.

CONCLUSIONS

The acrylic foldable IOL adhered to the lens capsule more than the PMMA IOL, and the silicone IOL showed no adhesiveness. These differences seem to play a role in preventing lens epithelial cells from migrating and forming posterior capsule opacification.

摘要

目的

研究几种人工晶状体（IOL）与模拟及兔晶状体囊膜的黏附特性。

方法

在水中测量聚甲基丙烯酸甲酯（PMMA）、三片式硅胶和丙烯酸可折叠IOL对牛胶原片的黏附力。在兔眼中进行超声乳化和IOL植入。三周后，测试前/后囊膜与IOL光学部之间的黏附情况，并对囊膜进行组织学检查。

结果

丙烯酸可折叠IOL对胶原片的平均黏附力为1697（标准差286）mg，PMMA为583（49）mg，硅胶IOL为0 mg（p = 0.0003，Kruskal-Wallis检验）。兔前囊膜与IOL光学部之间的黏附评分（0 - 5分），丙烯酸可折叠IOL为4.50（0.55），PMMA为3.20（0.84），硅胶IOL为0.40（0.55）（p = 0.004）。兔后囊膜与IOL光学部之间的评分呈现类似趋势；丙烯酸可折叠IOL为4.50（0.84），PMMA为3.00（1.00），硅胶IOL为0.40（0.55）（p = 0.021）。组织学观察表明，IOL光学部边缘抑制了晶状体上皮细胞向后囊膜中心的迁移。这种抑制作用在丙烯酸可折叠IOL中最为明显，在硅胶IOL中最不明显。

结论

丙烯酸可折叠IOL比PMMA IOL更易黏附于晶状体囊膜，而硅胶IOL无黏附性。这些差异似乎在防止晶状体上皮细胞迁移和形成后囊膜混浊中起作用。