Hareyama M, Nagakura H, Tamakawa M, Hyodo K, Asakura K, Horikoshi T, Tanaka S, Imai K, Hattori A, Oouchi A, Shido M, Koshiba H, Sakata K, Morita K
Department of Radiology, Sapporo Medical University, Japan.
Jpn J Clin Oncol. 1996 Jun;26(3):189-93. doi: 10.1093/oxfordjournals.jjco.a023206.
Collagen disease are frequently associated with malignant tumors. Recently, radiotherapy combined with chemotherapy has been recommended for improving the efficacy of treatment for nasopharyngeal carcinoma. Two patients with nasopharyngeal carcinoma complicated by collagen diseases (dermatomyositis in one, and Sjögren's syndrome with mixed connective tissue disease in the other) were given radiotherapy combined with chemotherapy consisting of cis-platinum and 5-fluorouracil. Following this combination therapy, both patients developed retropharyngeal abscess and ulceration of the mucosal membrane on the posterior wall of the oropharynx; there was no tumor cell involvement. Because these injuries were more severe than would have been expected from radiotherapy alone, it is recommended that special attention be paid to combination therapy in patients with nasopharyngeal carcinoma complicated by collagen disease.
胶原病常与恶性肿瘤相关。最近，推荐放疗联合化疗以提高鼻咽癌的治疗效果。两名鼻咽癌合并胶原病的患者（一名为皮肌炎，另一名为干燥综合征合并混合性结缔组织病）接受了由顺铂和5-氟尿嘧啶组成的放疗联合化疗。经过这种联合治疗后，两名患者均出现了咽后脓肿和口咽后壁黏膜溃疡；无肿瘤细胞浸润。由于这些损伤比单纯放疗预期的更严重，建议对鼻咽癌合并胶原病的患者进行联合治疗时要特别注意。
