[人类免疫缺陷病毒（HIV）感染中对叠氮胸苷的耐药性]
[Resistance to azidothymidine in human immunodeficiency virus (HIV) infection].
作者信息
Karmanov E V, Lukashov V V
出版信息
Mol Biol (Mosk). 1994 Jan-Feb;28(1):7-20.
PMID:7511784
Abstract
The phenomenon of resistance to azidothymidine during the infection of human immunodeficiency virus (HIV) is reviewed. Different aspects of AZT resistance, including biological and virological characteristics of resistant HIV isolates, genetical mechanisms of resistance, cross-resistance to other nucleoside analogs and non-nucleoside inhibitors, are analyzed. The role of target cells in AZT resistance is also discussed.
摘要
综述了人类免疫缺陷病毒（HIV）感染过程中对叠氮胸苷产生耐药性的现象。分析了叠氮胸苷耐药性的不同方面，包括耐药HIV分离株的生物学和病毒学特征、耐药的遗传机制、对其他核苷类似物和非核苷抑制剂的交叉耐药性。还讨论了靶细胞在叠氮胸苷耐药性中的作用。
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