Krysiak B
Zakładu Oceny Toksyczności, Instytut Medycyny Pracy, Lodzi.
Med Pr. 1996;47(2):143-9.
The irritative effect of formaldehyde and glutaraldehyde on the rabbit skin was determined under conditions of a single, closed exposure and under conditions of multiple, open exposure. It was revealed that the irritative effect was dependent on the concentration used, application mode and exposure duration. Under conditions of a single, 4 and 24-hour, closed exposure, threshold concentration which was inducing only slight inflammatory reaction of skin was equal to 2% of aqueous solution for both formaldehyde and glutaraldehyde. Under conditions of a 10 open exposure, threshold concentration of irritative effect on the skin was determined as 5% aqueous solution for formaldehyde and 2.5% aqueous solution for glutaraldehyde. A single administration of 0.5% aqueous solution of formaldehyde and of 0.2% aqueous solution of glutaraldehyde into the rabbit's eye induced a slight and short lasting inflammatory reaction. These concentrations were recognised as threshold ones.
在单次封闭暴露和多次开放暴露条件下，测定了甲醛和戊二醛对兔皮肤的刺激作用。结果表明，刺激作用取决于所用浓度、施用方式和暴露持续时间。在单次4小时和24小时封闭暴露条件下，仅引起皮肤轻微炎症反应的阈浓度，甲醛和戊二醛的水溶液均为2%。在10次开放暴露条件下，对皮肤产生刺激作用的阈浓度，甲醛为5%水溶液，戊二醛为2.5%水溶液。将0.5%甲醛水溶液和0.2%戊二醛水溶液单次滴入兔眼，引起轻微且持续时间短的炎症反应。这些浓度被认为是阈浓度。
