• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Interaction of C/EBPbeta and v-Myb is required for synergistic activation of the mim-1 gene.C/EBPβ与v-Myb的相互作用是mim-1基因协同激活所必需的。
Mol Cell Biol. 1996 Apr;16(4):1316-25. doi: 10.1128/MCB.16.4.1316.
2
Synergistic activation of the chicken mim-1 gene by v-myb and C/EBP transcription factors.v-myb和C/EBP转录因子对鸡mim-1基因的协同激活作用。
EMBO J. 1993 May;12(5):2027-38. doi: 10.1002/j.1460-2075.1993.tb05852.x.
3
v-Myb mediates cooperation of a cell-specific enhancer with the mim-1 promoter.v-Myb介导细胞特异性增强子与mim-1启动子的协同作用。
Mol Cell Biol. 2005 Jan;25(1):499-511. doi: 10.1128/MCB.25.1.499-511.2005.
4
The v-Myb oncoprotein activates C/EBPbeta expression by stimulating an autoregulatory loop at the C/EBPbeta promoter.v-Myb癌蛋白通过刺激C/EBPβ启动子处的自调节环来激活C/EBPβ的表达。
Biochim Biophys Acta. 1999 Oct 28;1447(2-3):175-84. doi: 10.1016/s0167-4781(99)00168-2.
5
Interaction and functional collaboration of p300 and C/EBPbeta.p300与C/EBPβ的相互作用及功能协作
Mol Cell Biol. 1997 Nov;17(11):6609-17. doi: 10.1128/MCB.17.11.6609.
6
Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell types.Myb和NF-M：异源细胞类型中髓系基因的组合激活因子。
Genes Dev. 1993 May;7(5):749-59. doi: 10.1101/gad.7.5.749.
7
C/EBPbeta induces chromatin opening at a cell-type-specific enhancer.C/EBPβ在细胞类型特异性增强子处诱导染色质开放。
Mol Cell Biol. 2008 Mar;28(6):2102-12. doi: 10.1128/MCB.01943-07. Epub 2008 Jan 14.
8
Mutations in the DNA-binding and transcriptional activation domains of v-Myb cooperate in transformation.v-Myb的DNA结合域和转录激活域中的突变在转化过程中协同作用。
J Virol. 1995 Apr;69(4):2515-24. doi: 10.1128/JVI.69.4.2515-2524.1995.
9
Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor.新型人类髓样细胞特异性C/EBP-ε转录因子的克隆
Mol Cell Biol. 1997 Mar;17(3):1375-86. doi: 10.1128/MCB.17.3.1375.
10
C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters.C/EBPε 直接与 c-myb 的 DNA 结合结构域相互作用，并协同激活髓系启动子的转录。
Blood. 1999 May 15;93(10):3327-37.

引用本文的文献

1
A chemical probe for BAG1 targets androgen receptor-positive prostate cancer through oxidative stress signaling pathway.一种针对BAG1的化学探针通过氧化应激信号通路靶向雄激素受体阳性前列腺癌。
iScience. 2022 Mar 31;25(5):104175. doi: 10.1016/j.isci.2022.104175. eCollection 2022 May 20.
2
Natural Products with Antitumor Potential Targeting the MYB-C/EBPβ-p300 Transcription Module.具有抗肿瘤潜力的天然产物靶向 MYB-C/EBPβ-p300 转录模块。
Molecules. 2022 Mar 23;27(7):2077. doi: 10.3390/molecules27072077.
3
C/EBPβ is a MYB- and p300-cooperating pro-leukemogenic factor and promising drug target in acute myeloid leukemia.C/EBPβ 是一种 MYB 和 p300 合作的促白血病发生因子，是急性髓系白血病中有前途的药物靶点。
Oncogene. 2021 Jul;40(29):4746-4758. doi: 10.1038/s41388-021-01800-x. Epub 2021 May 6.
4
MYB oncoproteins: emerging players and potential therapeutic targets in human cancer.MYB癌蛋白：人类癌症中新兴的参与者和潜在的治疗靶点。
Oncogenesis. 2021 Feb 26;10(2):19. doi: 10.1038/s41389-021-00309-y.
5
c-Myb and C/EBPβ regulate OPN and other senescence-associated secretory phenotype factors.c-Myb和C/EBPβ调节骨桥蛋白及其他衰老相关分泌表型因子。
Oncotarget. 2017 Dec 5;9(1):21-36. doi: 10.18632/oncotarget.22940. eCollection 2018 Jan 2.
6
The natural anti-tumor compound Celastrol targets a Myb-C/EBPβ-p300 transcriptional module implicated in myeloid gene expression.天然抗肿瘤化合物雷公藤红素靶向一个与髓系基因表达相关的Myb-C/EBPβ-p300转录模块。
PLoS One. 2018 Feb 2;13(2):e0190934. doi: 10.1371/journal.pone.0190934. eCollection 2018.
7
A c-Myb mutant causes deregulated differentiation due to impaired histone binding and abrogated pioneer factor function.一种c-Myb突变体由于组蛋白结合受损和先驱因子功能丧失而导致分化失调。
Nucleic Acids Res. 2017 Jul 27;45(13):7681-7696. doi: 10.1093/nar/gkx364.
8
Helenalin Acetate, a Natural Sesquiterpene Lactone with Anti-inflammatory and Anti-cancer Activity, Disrupts the Cooperation of CCAAT Box/Enhancer-binding Protein β (C/EBPβ) and Co-activator p300.醋酸海伦内酯，一种具有抗炎和抗癌活性的天然倍半萜内酯，破坏CCAAT盒/增强子结合蛋白β（C/EBPβ）与共激活因子p300的协作。
J Biol Chem. 2016 Dec 9;291(50):26098-26108. doi: 10.1074/jbc.M116.748129. Epub 2016 Nov 1.
9
c-Myb regulates cell cycle-dependent expression of Erbin: an implication for a novel function of Erbin.c-Myb 调控 Erbin 的细胞周期依赖性表达：Erbin 新功能的一种暗示。
PLoS One. 2012;7(8):e42903. doi: 10.1371/journal.pone.0042903. Epub 2012 Aug 7.
10
Myb-induced chromatin remodeling at a dual enhancer/promoter element involves non-coding rna transcription and is disrupted by oncogenic mutations of v-myb.Myb 诱导的双重增强子/启动子元件染色质重塑涉及非编码 RNA 转录，并被 v-myb 的致癌突变所破坏。
J Biol Chem. 2009 Dec 18;284(51):35314-24. doi: 10.1074/jbc.M109.066175.

本文引用的文献

1
Synergistic activation of the chicken mim-1 gene by v-myb and C/EBP transcription factors.v-myb和C/EBP转录因子对鸡mim-1基因的协同激活作用。
EMBO J. 1993 May;12(5):2027-38. doi: 10.1002/j.1460-2075.1993.tb05852.x.
2
The NF-M transcription factor is related to C/EBP beta and plays a role in signal transduction, differentiation and leukemogenesis of avian myelomonocytic cells.NF-M转录因子与C/EBPβ相关，在禽骨髓单核细胞的信号转导、分化和白血病发生过程中发挥作用。
EMBO J. 1993 Apr;12(4):1321-32. doi: 10.1002/j.1460-2075.1993.tb05777.x.
3
A nuclear factor for interleukin-6 expression (NF-IL6) and the glucocorticoid receptor synergistically activate transcription of the rat alpha 1-acid glycoprotein gene via direct protein-protein interaction.白细胞介素-6表达的核因子（NF-IL6）与糖皮质激素受体通过直接的蛋白质-蛋白质相互作用协同激活大鼠α1-酸性糖蛋白基因的转录。
Mol Cell Biol. 1993 Mar;13(3):1854-62. doi: 10.1128/mcb.13.3.1854-1862.1993.
4
Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6.由ras依赖性丝裂原活化蛋白激酶级联反应在苏氨酸-235位点进行的磷酸化对于转录因子NF-IL6至关重要。
Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2207-11. doi: 10.1073/pnas.90.6.2207.
5
Mineralocorticoid and glucocorticoid receptor activities distinguished by nonreceptor factors at a composite response element.在复合反应元件处，盐皮质激素和糖皮质激素受体活性由非受体因子区分。
Science. 1993 Feb 19;259(5098):1161-5. doi: 10.1126/science.8382376.
6
Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain.NF-IL6/LAP的反式激活作用通过其激活结构域的磷酸化得以增强。
Nature. 1993 Aug 5;364(6437):544-7. doi: 10.1038/364544a0.
7
Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region.Fos和Jun通过在碱性拉链区域的结合抑制NF-IL6的转录激活。
Mol Cell Biol. 1994 Jan;14(1):268-76. doi: 10.1128/mcb.14.1.268-276.1994.
8
The chicken A-myb protein is a transcriptional activator.鸡A-myb蛋白是一种转录激活因子。
Oncogene. 1994 Sep;9(9):2481-8.
9
Novel mechanism of C/EBP beta (NF-M) transcriptional control: activation through derepression.C/EBPβ（NF-M）转录调控的新机制：通过去抑制实现激活。
Genes Dev. 1994 Nov 15;8(22):2781-91. doi: 10.1101/gad.8.22.2781.
10
Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell types.Myb和NF-M：异源细胞类型中髓系基因的组合激活因子。
Genes Dev. 1993 May;7(5):749-59. doi: 10.1101/gad.7.5.749.

C/EBPβ与v-Myb的相互作用是mim-1基因协同激活所必需的。

Interaction of C/EBPbeta and v-Myb is required for synergistic activation of the mim-1 gene.

作者信息

Mink S, Kerber U, Klempnauer K H

机构信息

Hans Spemann Laboratory, Max Planck Institute for Immunobiology, Freiburg, Germany.

出版信息

Mol Cell Biol. 1996 Apr;16(4):1316-25. doi: 10.1128/MCB.16.4.1316.

DOI:10.1128/MCB.16.4.1316
PMID:8657104
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC231115/
Abstract

The retroviral oncogene v-myb encodes a transcription factor (v-Myb) which activates the myelomonocyte-specific mim-1 gene, a natural myb target gene, by cooperating with members of the C/EBP transcription factor family. The finding that v-Myb, together with C/EBP, is sufficient to activate the mim-1 gene in heterologous cell types has implicated Myb and C/EBP as a bipartite molecular switch, which regulates the expression of myelomonocyte-specific genes. To understand the relationship between v-Myb and C/EBP in more detail, we have examined the molecular basis of the activation of the mim-1 promoter by v-Myb and C/EBPbeta, a member of the C/EBP transcription factor family highly expressed in myelomonocytic cells. We have identified a composite Myb and C/EBP response element which mediates synergistic activation of the mim-1 promoter by both factors and consists of closely spaced Myb- and C/EBP-binding sites. In vitro and in vivo protein-binding studies indicate that v-Myb and C/EBPbeta interact with each other via their DNA-binding domains. We show that this interaction is essential for the synergistic activation of the mim-1 promoter by v-Myb and C/EBPbeta. Our work therefore identifies C/EBPbeta as an interaction partner of v-Myb involved in myelomonocyte gene expression.

摘要

逆转录病毒癌基因v-myb编码一种转录因子（v-Myb），该转录因子通过与C/EBP转录因子家族成员协同作用，激活天然myb靶基因——骨髓单核细胞特异性mim-1基因。v-Myb与C/EBP共同足以在异源细胞类型中激活mim-1基因，这一发现表明Myb和C/EBP是一种二元分子开关，可调节骨髓单核细胞特异性基因的表达。为了更详细地了解v-Myb与C/EBP之间的关系，我们研究了v-Myb和C/EBPβ（在骨髓单核细胞中高表达的C/EBP转录因子家族成员）激活mim-1启动子的分子基础。我们鉴定出一个复合的Myb和C/EBP反应元件，它介导了这两种因子对mim-1启动子的协同激活，并且由紧密间隔的Myb结合位点和C/EBP结合位点组成。体外和体内蛋白质结合研究表明，v-Myb和C/EBPβ通过它们的DNA结合结构域相互作用。我们表明这种相互作用对于v-Myb和C/EBPβ协同激活mim-1启动子至关重要。因此，我们的工作确定C/EBPβ是参与骨髓单核细胞基因表达的v-Myb的相互作用伙伴。