Gocke E, Albertini S
Department of Toxicology, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
Mutat Res. 1996 Feb 19;350(1):51-7. doi: 10.1016/0027-5107(95)00090-9.
A number of structurally very diverse compounds which cause weak positive effects in the Ames test by evident or suspect irrelevant mechanisms is discussed. As a unifying observation we describe synergistic effects in combination with known mutagens in the responsive strains and comutagenic effects in initially unresponsive strains. We argue that the compounds enhance the formation of spontaneous (or mutagen-induced) revertant colonies by test-specific mechanisms likely to be of no relevance to multicellular eukaryotic organisms rather than possessing intrinsic genotoxic (i.e. DNa-damaging) properties in the Ames test.
本文讨论了一些结构非常多样的化合物，这些化合物通过明显或可疑的不相关机制在艾姆斯试验中产生微弱的阳性效应。作为一个统一的观察结果，我们描述了在反应性菌株中与已知诱变剂联合时的协同效应，以及在最初无反应的菌株中的共诱变效应。我们认为，这些化合物通过可能与多细胞真核生物无关的试验特异性机制增强自发（或诱变剂诱导）回复菌落的形成，而不是在艾姆斯试验中具有内在的遗传毒性（即DNA损伤）特性。
