[结核分枝杆菌的S型和R型作为产生克隆和表型有活性菌株的一个问题]
[S and R forms of Mycobacterium tuberculosis as a problem of producing cloned and phenotypically competent strains].
作者信息
Korneev A A, Puzanov V A, Grishina T D, Chernousova L N, Kalinina O A, Musabekova N V
出版信息
Probl Tuberk. 1996(2):36-40.
The authors suggest that animals and humans carry M. tuberculosis in S form. These mycobacteria are virulent, do not form conglomerates and represent biologically most potent form. The state of R-form M. tuberculosis results from their culturing on artificial culture media which fail to secure compatible conditions for cells. M. tuberculosis S-form is convenient for microbiological and molecular-genetic research. The authors offer a method of biological production of single M. tuberculosis in S form.
作者认为动物和人类携带S型结核分枝杆菌。这些分枝杆菌具有致病性，不形成聚集体，是生物学上最具活性的形式。结核分枝杆菌R型状态是由于在未能为细胞提供适宜条件的人工培养基上培养所致。结核分枝杆菌S型便于进行微生物学和分子遗传学研究。作者提供了一种生物制备单个S型结核分枝杆菌的方法。
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