定量心脏灌注：一种利用冠状动脉血管几何结构的无创自旋标记方法。
Quantitative cardiac perfusion: a noninvasive spin-labeling method that exploits coronary vessel geometry.
作者信息
Reeder S B, Atalay M K, McVeigh E R, Zerhouni E A, Forder J R
机构信息
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
出版信息
Radiology. 1996 Jul;200(1):177-84. doi: 10.1148/radiology.200.1.8657907.
PURPOSE
To quantitate myocardial arterial perfusion with a noninvasive magnetic resonance (MR) imaging technique that exploits the geometry of coronary vessel anatomy.
MATERIALS AND METHODS
MR imaging was performed with a spin-labeling method in six arrested rabbit hearts at 4.7 T. Selective inversion of magnetization in the short-axis imaging section along with all myocardium apical to that section produces signal enhancement from arterial perfusion. A linescan protocol was used for validation of flow enhancement. Flow was quantitated from two images and validated with spin-echo (SE) imaging. Regional perfusion defects were created by means of coronary artery ligation and delineated with gadolinium-enhanced imaging.
RESULTS
Linescan estimates of T1 obtained at physiologic flows agreed with model predictions. Flow-induced signal enhancement measured on SE images also agreed with expected values. Finally, perfusion abnormalities created by means of coronary artery ligation were detected.
CONCLUSION
This spin-labeling method provides quantitative estimates of myocardial arterial perfusion in this model and may hold promise for clinical applications.
目的
利用冠状动脉血管解剖结构的几何形状，通过一种非侵入性磁共振（MR）成像技术对心肌动脉灌注进行定量分析。
材料与方法
采用自旋标记法在6只停搏的兔心脏上于4.7 T磁场下进行MR成像。在短轴成像层面以及该层面心尖方向的所有心肌中进行选择性磁化反转，从而产生动脉灌注引起的信号增强。采用线扫描方案验证血流增强情况。从两幅图像中对血流进行定量分析，并通过自旋回波（SE）成像进行验证。通过冠状动脉结扎制造局部灌注缺损，并采用钆增强成像进行描绘。
结果
在生理血流情况下获得的线扫描T1估计值与模型预测结果相符。在SE图像上测量的血流诱导信号增强也与预期值相符。最后，检测到了通过冠状动脉结扎造成的灌注异常情况。
结论
这种自旋标记方法可对该模型中的心肌动脉灌注进行定量估计，在临床应用方面可能具有前景。
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