胆囊切除术作为结直肠癌的一个危险因素：一项荟萃分析。
Cholecystectomy as a risk factor for colorectal cancer: a meta-analysis.
作者信息
Reid F D, Mercer P M, harrison M, Bates T
机构信息
Dept. of Public Health and Epidemiology, King's College School of Medicine and Dentistry, London, UK.
出版信息
Scand J Gastroenterol. 1996 Feb;31(2):160-9. doi: 10.3109/00365529609031981.
BACKGROUND
It has been suggested that there is an increased risk of colorectal cancer after cholecystectomy due to increased levels of secondary bile acids. Some studies suggest the risk is higher for women and for the development of right-sided tumours.
METHODS
A review of the literature yielded 95 relevant studies, of which 35 were suitable for a meta-analysis involving age- and sex-matched controls.
RESULTS
The pooled odds ratio for a positive association between cholecystectomy and colorectal cancer was 1.11 (95% confidence interval (CI), 1.02 to 1.21). For women the odds ratio was 1.14 (95 % CI, 10.01 to 1.28) and for right-sided cancer 1.86 (95% CI, 1.31 to 2.65).
CONCLUSIONS
It is possible that this small observed association may be due to a publication bias for positive results or bias within the included studies. If it is indeed a real effect, the risk to an individual is very small.
背景
有人提出，由于次级胆汁酸水平升高，胆囊切除术后患结直肠癌的风险增加。一些研究表明，女性以及右侧肿瘤发生的风险更高。
方法
对文献进行回顾后得到95项相关研究，其中35项适合进行荟萃分析，纳入了年龄和性别匹配的对照组。
结果
胆囊切除术与结直肠癌之间呈正相关的合并比值比为1.11（95%置信区间（CI），1.02至1.21）。女性的比值比为1.14（95%CI，10.01至1.28），右侧癌症的比值比为1.86（95%CI，1.31至2.65）。
结论
观察到的这种小关联可能是由于对阳性结果的发表偏倚或纳入研究中的偏倚所致。如果这确实是一种真实效应，那么个体风险非常小。
Zotero 插件