胆囊切除术与肿瘤错配修复缺陷状态下的结直肠癌风险
Cholecystectomy and the risk of colorectal cancer by tumor mismatch repair deficiency status.
作者信息
Shang Jie, Reece Jeanette C, Buchanan Daniel D, Giles Graham G, Figueiredo Jane C, Casey Graham, Gallinger Steven, Thibodeau Stephen N, Lindor Noralane M, Newcomb Polly A, Potter John D, Baron John A, Hopper John L, Jenkins Mark A, Win Aung Ko
机构信息
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia.
出版信息
Int J Colorectal Dis. 2016 Aug;31(8):1451-7. doi: 10.1007/s00384-016-2615-5. Epub 2016 Jun 10.
PURPOSE
Gallbladder diseases and cholecystectomy may play a role in the development of colorectal cancer (CRC). Our aim was to investigate the association between cholecystectomy and CRC risk overall and by sex, family history, anatomical location, and tumor mismatch repair (MMR) status.
METHODS
This study comprised 5847 incident CRC cases recruited from population cancer registries in Australia, Canada, and the USA into the Colon Cancer Family Registry between 1997 and 2012 and 4970 controls with no personal history of CRC who were either randomly selected from the general population or were spouses of the cases. The association between cholecystectomy and CRC was estimated using logistic regression, after adjusting for confounding factors.
RESULTS
Overall, there was no evidence for an association between cholecystectomy and CRC (odds ratio [OR] = 0.88, 95 % confidence interval 0.73, 1.08). In the stratified analyses, there was no evidence for a difference in the association between women and men (P = 0.54), between individuals with and without family history of CRC in first-degree relative (P = 0.64), between tumor anatomical locations (P = 0.45), or between MMR-proficient and MMR-deficient cases (P = 0.54).
CONCLUSION
Cholecystectomy is not a substantial risk factor for CRC, regardless of sex, family history, anatomical location, or tumor MMR status.
目的
胆囊疾病和胆囊切除术可能在结直肠癌（CRC）的发生发展中起作用。我们的目的是总体上以及按性别、家族史、解剖位置和肿瘤错配修复（MMR）状态研究胆囊切除术与CRC风险之间的关联。
方法
本研究纳入了1997年至2012年间从澳大利亚、加拿大和美国的人群癌症登记处招募到结肠癌家族登记处的5847例新发CRC病例，以及4970名无CRC个人史的对照，这些对照要么是从普通人群中随机选取的，要么是病例的配偶。在调整混杂因素后，使用逻辑回归估计胆囊切除术与CRC之间的关联。
结果
总体而言，没有证据表明胆囊切除术与CRC之间存在关联（优势比[OR]=0.88，95%置信区间0.73，1.08）。在分层分析中，没有证据表明女性与男性之间（P=0.54）、有和无一级亲属CRC家族史的个体之间（P=0.64）、肿瘤解剖位置之间（P=0.45）或MMR功能正常与MMR缺陷病例之间（P=0.54）的关联存在差异。
结论
无论性别、家族史、解剖位置或肿瘤MMR状态如何，胆囊切除术都不是CRC的重要危险因素。
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