[中国人群胆囊切除术或胆囊结石与结直肠癌风险相关性的Meta分析]

[Meta-analysis on the correlation of cholecystectomy or cholecystolithiasis to risk of colorectal cancer in Chinese population].

作者信息

Xu Yi-Ke, Zhang Feng-Lan, Feng Tao, Li Jin, Wang Yun-Hai

机构信息

Department of Gastrointestinal Surgery, Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China.

出版信息

Ai Zheng. 2009 Jul;28(7):749-55. doi: 10.5732/cjc.008.10829.

DOI:10.5732/cjc.008.10829

PMID:19624904

Abstract

BACKGROUND AND OBJECTIVE

It is reported that the incidence of colorectal cancer is higher in patients receiving cholecystectomy (CHE) than in those who did not. However, the correlation of CHE and cholecystolithiasis (CHO) to colorectal cancer is unclear. This study was to investigate the correlation of CHE or CHO to risk of colorectal cancer in Chinese population.

METHODS

A meta-analysis was conducted according to the guidelines set forth by the meta-analysis of observational studies in epidemiology (MOOSE statement). A manual and computer search of literature was performed. Included literatures were evaluated using the Newcastle-Ottawa Scale. Original data were extracted, pooled odd ratio (OR) and 95% confidence intervals (Cl) were calculated using revman 5.0.

RESULTS

In total 26 studies were included. The pooled OR between CHO or CHE, CHE alone, CHO alone and colorectal cancer were 3.00 (95%IC 2.30-3.91), 2.85 (95%IC 2.13-3.81) and 2.68 (95%IC 1.93-3.72), respectively. Sub-group analysis in sex and position of tumors revealed obvious correlation of CHE or CHO to colorectal cancer except for the men's subgroup.

CONCLUSION

CHE or CHO may be associated with colorectal cancer in Chinese population.

摘要

背景与目的

据报道，接受胆囊切除术（CHE）的患者结直肠癌发病率高于未接受该手术的患者。然而，CHE和胆囊结石（CHO）与结直肠癌之间的相关性尚不清楚。本研究旨在探讨CHE或CHO与中国人群结直肠癌风险的相关性。

方法

根据流行病学观察性研究的荟萃分析（MOOSE声明）指南进行荟萃分析。通过手工和计算机检索文献。使用纽卡斯尔-渥太华量表对纳入的文献进行评估。提取原始数据，使用RevMan 5.0计算合并比值比（OR）和95%置信区间（CI）。

结果

共纳入26项研究。CHO或CHE、单独CHE、单独CHO与结直肠癌之间的合并OR分别为3.00（95%CI 2.30 - 3.91）、2.85（95%CI 2.13 - 3.81）和2.68（95%CI 1.93 - 3.72）。按性别和肿瘤位置进行的亚组分析显示，除男性亚组外，CHE或CHO与结直肠癌存在明显相关性。