Nyberg P, Söderblom T, Pettersson T, Riska H, Klockars M, Linko L
Mjölbolsta Hospital, Finland.
Thorax. 1996 Jan;51(1):92-4. doi: 10.1136/thx.51.1.92.
High pleural fluid levels of neurone-specific enolase (NSE) have been reported, not only in patients with small cell lung cancer but also in those with chronic inflammatory diseases.
NSE concentrations were determined in pleural fluid and serum from 342 patients with pleural effusions including 17 with rheumatoid arthritis.
The median NSE concentration in pleural fluid was higher in rheumatoid effusions than in any other condition studied. The median pleural fluid:serum NSE ratio was highest in patients with rheumatoid arthritis (11.6) and about unity in all other diseases including small cell lung cancer (0.9). In patients with rheumatoid arthritis pleural fluid concentrations of NSE correlated inversely with pleural fluid glucose concentrations and the pH of the pleural fluid.
A high pleural fluid:serum NSE ratio was found consistently in pleural effusions from patients with rheumatoid disease.
据报道,不仅小细胞肺癌患者,慢性炎症性疾病患者的胸腔积液中神经元特异性烯醇化酶(NSE)水平也较高。
测定了342例胸腔积液患者(包括17例类风湿关节炎患者)的胸腔积液和血清中的NSE浓度。
类风湿性胸腔积液中胸腔积液NSE浓度中位数高于所研究的任何其他情况。胸腔积液:血清NSE比值中位数在类风湿关节炎患者中最高(11.6),在包括小细胞肺癌在内的所有其他疾病中约为1(0.9)。类风湿关节炎患者胸腔积液中NSE浓度与胸腔积液葡萄糖浓度和胸腔积液pH值呈负相关。
在类风湿疾病患者的胸腔积液中始终发现较高的胸腔积液:血清NSE比值。