Wallis W J, Simkin P A, Nelp W B
Arthritis Rheum. 1985 Oct;28(10):1096-1104. doi: 10.1002/art.1780281004.
Iodide clearance was measured in the chronic knee effusions of 11 patients with rheumatoid arthritis and 9 patients with osteoarthritis. The mean (+/- SE) iodide clearance of 1.92 +/- 0.30 ml/minute in rheumatoid arthritis effusions did not differ significantly from the 2.19 +/- 0.52 ml/minute found in osteoarthritis effusions. Clearance values in rheumatoid arthritis patients ranged widely (0.79-3.22 ml/minute). Iodide clearance in these patients correlated directly with synovial fluid (SF) pH (r = 0.731, P = 0.005), SF glucose:serum glucose ratio (r = 0.746, P = 0.004), and SF temperature (r = 0.878, P = 0.001), and directly with SF lactate (r = -0.782, P = 0.002) and percentage of SF neutrophils (r = -0.581, P = 0.03). These relationships support the hypothesis that rheumatoid synovitis is often marked by tissue hypoperfusion, and that the "sickest" rheumatoid joints (as defined by physiologic indices) are the most ischemic.
对11例类风湿关节炎患者和9例骨关节炎患者的慢性膝关节积液进行了碘清除率测定。类风湿关节炎积液的平均（±标准误）碘清除率为1.92±0.30毫升/分钟，与骨关节炎积液中测得的2.19±0.52毫升/分钟无显著差异。类风湿关节炎患者的清除率值范围很广（0.79 - 3.22毫升/分钟）。这些患者的碘清除率与滑液（SF）pH值直接相关（r = 0.731，P = 0.005）、SF葡萄糖：血清葡萄糖比值（r = 0.746，P = 0.004）以及SF温度（r = 0.878，P = 0.001），并与SF乳酸（r = -0.782，P = 0.002）和SF中性粒细胞百分比（r = -0.581，P = 0.03）直接相关。这些关系支持了以下假设：类风湿滑膜炎常以组织灌注不足为特征，并且（根据生理指标定义）“病情最严重”的类风湿关节缺血最严重。
