Ayuk P, Williams N, Scott N A, Nicholson D A, Irving M H
Department of Surgery, University of Manchester, Hope Hospital, Salford.
Ann R Coll Surg Engl. 1996 Jan;78(1):5-10.
Over a 5-year period, 54 intra-abdominal abscesses were observed in 40 (20.8%) of 192 patients with Crohn's disease. The median age was 39 years (range 17-76 years); median interval from diagnosis, 7.5 years (range 0-24 years) and the median number of surgical operations was 2 (range 0-7). Forty abscesses (74.1%) were spontaneous and 14 (25.9%) were postoperative. Thirty abscesses were initially managed by laparotomy, 14 by percutaneous drainage, nine by incision and drainage and in one case the abscess drained spontaneously. Intra-abdominal abscesses were managed successfully by laparotomy in 23 (76.7%) of 30 patients, with a 93% success rate (13 of 14) for spontaneous abscesses managed by resection and primary anastomosis. Three of 8 (37.5%) spontaneous abscesses were managed successfully by percutaneous drainage, a temporising effect being achieved in a further two cases. There was no significant difference in sepsis score or duration of hospital stay for patients managed initially by laparotomy and those managed by drainage. However, patients with stricturing or fistulating Crohn's disease were much more likely to have initial management by laparotomy and in these patients surgical intervention was found to be an effective initial strategy.
在5年期间,192例克罗恩病患者中有40例(20.8%)出现了54例腹腔内脓肿。中位年龄为39岁(范围17 - 76岁);自诊断起的中位间隔时间为7.5年(范围0 - 24年),手术操作的中位次数为2次(范围0 - 7次)。40例脓肿(74.1%)为自发性,14例(25.9%)为术后脓肿。30例脓肿最初通过剖腹手术处理,14例通过经皮引流处理,9例通过切开引流处理,1例脓肿自行破溃。30例患者中23例(76.7%)通过剖腹手术成功处理腹腔内脓肿,通过切除和一期吻合术处理的自发性脓肿成功率为93%(14例中的13例)。8例自发性脓肿中有3例(37.5%)通过经皮引流成功处理,另有2例取得了暂时的效果。最初通过剖腹手术处理的患者与通过引流处理的患者在脓毒症评分或住院时间方面没有显著差异。然而,患有狭窄或瘘管性克罗恩病的患者更有可能最初通过剖腹手术处理,并且在这些患者中,手术干预被发现是一种有效的初始策略。