来自人软骨的IX型胶原蛋白：分子间交联位点的结构概况。
Collagen type IX from human cartilage: a structural profile of intermolecular cross-linking sites.
作者信息
Diab M, Wu J J, Eyre D R
机构信息
Department of Orthopaedics, University of Washington, Seattle 98195-6500, USA.
出版信息
Biochem J. 1996 Feb 15;314 ( Pt 1)(Pt 1):327-32. doi: 10.1042/bj3140327.
Abstract
Type IX collagen, a quantitatively minor collagenous component of cartilage, is known to be associated with and covalently cross-linked to type II collagen fibrils in chick and bovine cartilage. Type IX collagen molecules have also been shown to form covalent cross-links with each other in bovine cartilage. In the present study we demonstrate by structural analysis and location of cross-linking sites that, in human cartilage, type IX collagen is covalently cross-linked to type II collagen and to other molecules of type IX collagen. We also present evidence that, if the proteoglycan form of type IX collagen is present in human cartilage, it can only be a minor component of the matrix, similar to findings with bovine cartilage.
摘要
IX型胶原蛋白是软骨中含量较少的胶原成分，已知在鸡和牛的软骨中，它与II型胶原纤维相关联并共价交联。在牛软骨中，IX型胶原蛋白分子也已被证明彼此之间能形成共价交联。在本研究中，我们通过结构分析和交联位点定位证明，在人类软骨中，IX型胶原蛋白与II型胶原蛋白以及其他IX型胶原蛋白分子共价交联。我们还提供了证据表明，如果人类软骨中存在IX型胶原蛋白的蛋白聚糖形式，它也只能是基质中的次要成分，这与牛软骨的研究结果类似。
相似文献
1
Collagen type IX from human cartilage: a structural profile of intermolecular cross-linking sites.来自人软骨的IX型胶原蛋白：分子间交联位点的结构概况。
Biochem J. 1996 Feb 15;314 ( Pt 1)(Pt 1):327-32. doi: 10.1042/bj3140327.
2
3
Two-dimensional peptide mapping of cross-linked type IX collagen in human cartilage.人软骨中交联IX型胶原蛋白的二维肽图谱分析
Arch Biochem Biophys. 2000 Jun 1;378(1):33-9. doi: 10.1006/abbi.2000.1805.
4
Covalent cross-linking of the NC1 domain of collagen type IX to collagen type II in cartilage.软骨中IX型胶原蛋白的NC1结构域与II型胶原蛋白的共价交联。
J Biol Chem. 2004 Jan 23;279(4):2568-74. doi: 10.1074/jbc.M311653200. Epub 2003 Nov 5.
5
Structural analysis of cross-linking domains in cartilage type XI collagen. Insights on polymeric assembly.软骨XI型胶原交联结构域的结构分析。对聚合物组装的见解。
J Biol Chem. 1995 Aug 11;270(32):18865-70. doi: 10.1074/jbc.270.32.18865.
6
Identification of hydroxypyridinium cross-linking sites in type II collagen of bovine articular cartilage.牛关节软骨II型胶原中羟基吡啶交联位点的鉴定
Biochemistry. 1984 Apr 10;23(8):1850-7. doi: 10.1021/bi00303a041.
7
Covalent interactions of type IX collagen in cartilage.软骨中IX型胶原蛋白的共价相互作用。
Connect Tissue Res. 1989;20(1-4):241-6. doi: 10.3109/03008208909023893.
8
The collagens of articular cartilage.关节软骨的胶原蛋白。
Semin Arthritis Rheum. 1991 Dec;21(3 Suppl 2):2-11. doi: 10.1016/0049-0172(91)90035-x.
9
Collagen type IX: evidence for covalent linkages to type II collagen in cartilage.IX型胶原蛋白：软骨中与II型胶原蛋白共价连接的证据。
FEBS Lett. 1987 Aug 17;220(2):337-41. doi: 10.1016/0014-5793(87)80842-6.
引用本文的文献
1
Proteins and pathways involved in inflammation are longitudinally associated with total body bone mineral density among primarily Hispanic overweight/obese adolescents and young adults.在主要为西班牙裔的超重/肥胖青少年和年轻成年人中，参与炎症反应的蛋白质和信号通路与全身骨矿物质密度存在纵向关联。
J Bone Miner Res. 2025 Mar 15;40(3):372-381. doi: 10.1093/jbmr/zjaf002.
2
Collagen type II: From biosynthesis to advanced biomaterials for cartilage engineering.II型胶原蛋白：从生物合成到用于软骨工程的先进生物材料
Biomater Biosyst. 2021 Nov 22;4:100030. doi: 10.1016/j.bbiosy.2021.100030. eCollection 2021 Dec.
3
Sexual Dimorphism in the Extracellular and Pericellular Matrix of Articular Cartilage.关节软骨细胞外基质和细胞周基质的性别二态性。
Cartilage. 2022 Jul-Sep;13(3):19476035221121792. doi: 10.1177/19476035221121792.
4
Depth-Dependent Glycosaminoglycan Concentration in Articular Cartilage by Quantitative Contrast-Enhanced Micro-Computed Tomography.通过定量对比增强微型计算机断层扫描术测定关节软骨中糖胺聚糖浓度的深度依赖性
Cartilage. 2015 Oct;6(4):216-25. doi: 10.1177/1947603515596418.
5
The cysteine-rich region of type VII collagen is a cystine knot with a new topology.VII 型胶原富含半胱氨酸区域是一个新拓扑结构的胱氨酸结。
J Biol Chem. 2014 Feb 21;289(8):4861-9. doi: 10.1074/jbc.M113.531327. Epub 2014 Jan 2.
6
Intervertebral discs from spinal nondeformity and deformity patients have different mechanical and matrix properties.来自脊柱无畸形和畸形患者的椎间盘具有不同的力学和基质特性。
Spine J. 2014 Mar 1;14(3):522-30. doi: 10.1016/j.spinee.2013.06.089. Epub 2013 Nov 15.
7
Type IX collagen neo-deposition in degenerative discs of surgical patients whether genotyped plus or minus for COL9 risk alleles.手术患者退变椎间盘内 9 型胶原新沉积，不论 COL9 风险等位基因基因型阳性或阴性。
Spine (Phila Pa 1976). 2011 Nov 15;36(24):2031-8. doi: 10.1097/BRS.0b013e3181ffdd61.
8
The potential of human allogeneic juvenile chondrocytes for restoration of articular cartilage.人同种异体幼年软骨细胞用于修复关节软骨的潜力。
Am J Sports Med. 2010 Jul;38(7):1324-33. doi: 10.1177/0363546510361950. Epub 2010 Apr 27.
9
RNAi reduces expression and intracellular retention of mutant cartilage oligomeric matrix protein.RNAi 降低突变型软骨寡聚基质蛋白的表达和细胞内滞留。
PLoS One. 2010 Apr 22;5(4):e10302. doi: 10.1371/journal.pone.0010302.
10
Collagen IX is required for the integrity of collagen II fibrils and the regulation of vascular plexus formation in zebrafish caudal fins.IX型胶原蛋白对于斑马鱼尾鳍中II型胶原蛋白纤维的完整性以及血管丛形成的调节是必需的。
Dev Biol. 2009 Aug 15;332(2):360-70. doi: 10.1016/j.ydbio.2009.06.003. Epub 2009 Jun 6.
本文引用的文献
1
Abnormality of type IX collagen in a patient with diastrophic dysplasia.一名患骨发育不全症患者的IX型胶原蛋白异常。
Am J Med Genet. 1994 Feb 15;49(4):402-9. doi: 10.1002/ajmg.1320490411.
2
The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping.脊柱骨骺发育不良基因编码一种新型硫酸盐转运蛋白：通过精细结构连锁不平衡图谱进行定位克隆。
Cell. 1994 Sep 23;78(6):1073-87. doi: 10.1016/0092-8674(94)90281-x.
3
Identification of a new disulphide bonded collagen from cartilage.从软骨中鉴定出一种新的二硫键连接的胶原蛋白。
FEBS Lett. 1980 Nov 17;121(1):51-4. doi: 10.1016/0014-5793(80)81265-8.
4
Minor collagens of chicken hyaline cartilage.鸡透明软骨的次要胶原蛋白。
Biochemistry. 1981 Sep 15;20(19):5443-8. doi: 10.1021/bi00522a014.
5
6
Cartilage type IX collagen is cross-linked by hydroxypyridinium residues.IX型软骨胶原蛋白通过羟基吡啶残基交联。
Biochem Biophys Res Commun. 1984 Sep 28;123(3):1033-9. doi: 10.1016/s0006-291x(84)80237-5.
7
Identification of hydroxypyridinium cross-linking sites in type II collagen of bovine articular cartilage.牛关节软骨II型胶原中羟基吡啶交联位点的鉴定
Biochemistry. 1984 Apr 10;23(8):1850-7. doi: 10.1021/bi00303a041.
8
Purification and characterization of a rabbit bone metalloproteinase that degrades proteoglycan and other connective-tissue components.一种可降解蛋白聚糖及其他结缔组织成分的兔骨金属蛋白酶的纯化与特性分析
Biochem J. 1983 Mar 1;209(3):741-52. doi: 10.1042/bj2090741.
9
Synthesis and characterization of cDNA encoding a cartilage-specific short collagen.编码一种软骨特异性短胶原蛋白的cDNA的合成与表征
Proc Natl Acad Sci U S A. 1984 May;81(10):3014-8. doi: 10.1073/pnas.81.10.3014.
10
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
Nature. 1970 Aug 15;227(5259):680-5. doi: 10.1038/227680a0.
Zotero 插件