Kawakami H, Maruyama H, Yasunami M, Ohkubo H, Hara H, Saida T, Nakanishi S, Nakamura S
Third Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
Biochem Biophys Res Commun. 1996 Apr 5;221(1):199-204. doi: 10.1006/bbrc.1996.0569.
We cloned two rat cDNAs of brain basic helix-loop-helix factor 1 (BHF1). These have an identical coding region, contain 357 amino acids and exhibit 94.6% identity to MATH-2/NEX1 in the basic helix-loop-helix region. BHF1mRNAs are dominantly expressed in the brain particularly in the cerebellum, in the adult bovine, rat and mouse. Two shorter BHF1mRNAs (1.6 kb and 1.8 kb) were also detected in the mouse embryo, and these decreased in the developmental process. These results suggest that BHF1 may play important roles in cerebellum-specific functions and development of neurons.
我们克隆了两个大鼠脑碱性螺旋-环-螺旋因子1（BHF1）的cDNA。它们具有相同的编码区，包含357个氨基酸，并且在碱性螺旋-环-螺旋区域与MATH-2/NEX1具有94.6%的同一性。BHF1 mRNA在成年牛、大鼠和小鼠的脑中尤其是小脑中大量表达。在小鼠胚胎中也检测到了两种较短的BHF1 mRNA（1.6 kb和1.8 kb），并且它们在发育过程中减少。这些结果表明BHF1可能在小脑特异性功能和神经元发育中发挥重要作用。
