Drutel G, Kathmann M, Heron A, Schwartz J C, Arrang J M
Unité de Neurobiologie et Pharmacologie (U.109) de l'INSERM, Centre Paul Broca, Paris, France.
Biochem Biophys Res Commun. 1996 Aug 14;225(2):333-9. doi: 10.1006/bbrc.1996.1176.
Arnt2, a new member of the basic-helix-loop-helix transcription factor family, was cloned from rat brain cDNAs. Its deduced 712 amino acid sequence displays 63% identity with that of the aryl hydrocarbon receptor nuclear translocator (Arnt1) that was completely established. Whereas Arnt2 gene expression, established by Northern blotting and in situ hybridization histochemistry, occurred selectively in brain and kidney, that of Arnt1 was ubiquitous, suggesting that the two proteins play distinct roles, presumably via dimerization and DNA binding with different partners.
Arnt2是碱性螺旋-环-螺旋转录因子家族的一个新成员，它是从大鼠脑cDNA中克隆出来的。其推导的712个氨基酸序列与已完全确定的芳烃受体核转运蛋白（Arnt1）的序列有63%的同一性。通过Northern印迹法和原位杂交组织化学确定，Arnt2基因表达选择性地出现在脑和肾中，而Arnt1的基因表达则是普遍存在的，这表明这两种蛋白质可能通过与不同伴侣二聚化和结合DNA发挥不同的作用。
