Sherlock J K, Griffin D K, Delhanty J D, Parrington J M
Department of Genetics and Biometry, Galton Laboratory, University College London, United Kingdom.
Genomics. 1996 Apr 15;33(2):214-9. doi: 10.1006/geno.1996.0186.
Regions of DNA homology between human and marmoset (Callithrix jacchus) chromosomes have been demonstrated using fluorescence in situ hybridization. All 24 chromosome paints and two centromere repeat sequences from Homo sapiens (HSA) have been annealed to previously G-banded metaphase spreads of Callithrix jacchus. All human paint probes, except Y, successfully hybridized to marmoset chromosomes. Fifteen of them hybridized to one region only, seven to two regions, and paint 1 to three regions. Homologies proposed from previous banding comparisons have been confirmed for HSA 2, 4-6, 10-12, 18, 19, 21 and X and partially confirmed for HSA 1 and 3, but were not in agreement for HSA 14 and 17. Human centromere repeat sequences for X and 18 did not hybridize to marmoset chromosomes. Because, at present, there is the confusion situation of several different numbering systems for marmoset chromosomes, we propose a new simpler nomenclature based on descending order of chromosome size.
利用荧光原位杂交技术已证实了人类和狨猴（Callithrix jacchus）染色体之间的DNA同源区域。来自智人（HSA）的所有24种染色体涂染探针和两个着丝粒重复序列已与之前经G显带处理的狨猴中期染色体铺展进行杂交。除Y染色体外，所有人类涂染探针均成功与狨猴染色体杂交。其中15个探针仅与一个区域杂交，7个与两个区域杂交，探针1与三个区域杂交。先前通过带型比较提出的同源性在HSA 2、4 - 6、10 - 12、18、19、21和X染色体上得到了证实，在HSA 1和3染色体上部分得到证实，但在HSA 14和17染色体上未得到证实。X和18染色体的人类着丝粒重复序列未与狨猴染色体杂交。由于目前狨猴染色体存在几种不同编号系统的混乱情况，我们基于染色体大小降序提出了一种新的更简单的命名法。
